Elucidating the metabolic characteristics of pancreatic β-cells from patients with type 2 diabetes (T2D) using a genome-scale metabolic modeling - Paul, Abhijit; Azhar, Salman; Das, Phonindra Nath; Bairagi, Nandadulal; Chatterjee, Samrat (Computers in biology and medicine, 2022)
Keywords: Antioxidants; Beta cells; Cardiovascular diseases; Coupling; Coupling factors; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Endoplasmic reticulum; Fatty acids; Fatty Acids - metabolism; Gene expression; Genetic variation; Genome scale models of metabolism; Genomes; Glucose - metabolism; Heart diseases; Humans; Hyperglycemia; Insulin; Insulin - metabolism; Insulin resistance; Insulin secretion; Insulin-Secreting Cells; Internal Medicine; Metabolic flux; Metabolism; Metabolites; Mitochondria; Mitochondria - metabolism; Mitochondrial metabolism; Modelling; Other; Oxidation; Oxidative phosphorylation; Pancreas; Pathogenesis; Phosphorylation; Proteins; Public health; Reactive oxygen species; Secretion; Genome scale models of metabolism; Mitochondrial metabolism; Oxidative phosphorylation; Genetic variation; Coupling factors; Insulin secretion