The Oncolytic Avian Reovirus p17 Protein Inhibits Invadopodia Formation in Murine Melanoma Cancer Cells by Suppressing the FAK/Src Pathway and the Formation of theTKs5/NCK1 Complex - Hsu, Chao-Yu; Li, Jyun-Yi; Yang, En-Ying; Liao, Tsai-Ling; Wen, Hsiao-Wei; Tsai, Pei-Chien; Ju, Tz-Chuen; Lye, Lon-Fye; Nielsen, Brent L.; Liu, Hung-Jen (Viruses, 2024)
Keywords: Adaptor proteins; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Angiogenesis; Animals; Antibodies; Avian orthoreovirus; avian reoviruses; Breast cancer; Cancer; Cancer cells; Cell adhesion & migration; Cell cycle; Cell Line, Tumor; cell lines; Cell migration; Cell Movement; Cellular signal transduction; Efficiency; FAK/Src; Focal adhesion kinase; Focal Adhesion Kinase 1 - genetics; Focal Adhesion Kinase 1 - metabolism; Gelatinase B; Genomes; Health aspects; Kinases; Matrix metalloproteinase; Medical research; Medicine, Experimental; Melanoma; Melanoma, Experimental - pathology; Melanoma, Experimental - therapy; metalloproteinases; Metastasis; Mice; mutants; neoplasm cells; non-specific protein-tyrosine kinase; Oncolysis; Oncolytic Viruses - genetics; Oncolytic Viruses - physiology; Orthoreovirus, Avian - genetics; Orthoreovirus, Avian - physiology; p17; p17 Protein; p53 Protein; p53/PTEN; Phosphotransferases; Physiological aspects; Plasmids; Podosomes - metabolism; Proteins; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; PTEN protein; Rab40b; Reoviruses; Signal Transduction; Src protein; src-Family Kinases - genetics; src-Family Kinases - metabolism; TKs5/NCK1 complex; transcription (genetics); Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; tyrosine; Viral proteins; Viral Proteins - genetics; Viral Proteins - metabolism; Wound healing; Taiwan; United States--US; Rab40b; invadopodia; FAK/Src; p17; TKs5/NCK1 complex; MMP9; avian reoviruses; p53/PTEN