Cortical Thickness in Mild Traumatic Brain Injury

• Published in: Journal of neurotrauma Vol. 33; no. 20; pp. 1809 - 1817
• Main Authors: Govindarajan, Koushik A., Narayana, Ponnada A., Hasan, Khader M., Wilde, Elisabeth A., Levin, Harvey S., Hunter, Jill V., Miller, Emmy R., Patel, Vipul Kumar S., Robertson, Claudia S., McCarthy, James J.
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 15.10.2016
• Subjects: Adolescent; Adult; Atorvastatin Calcium - therapeutic use; Brain Concussion - diagnostic imaging; Brain Concussion - drug therapy; Brain Concussion - pathology; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - drug effects; Cerebral Cortex - pathology; Cross-Sectional Studies; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Magnetic Resonance Imaging; Male; Middle Aged; NMR; Nuclear magnetic resonance; Original; Thickness measurement; Traumatic brain injury; Young Adult; longitudinal analysis; orthopedic injury; mTBI; FreeSurfer; cortical thickness

Magnetic resonance imaging data were acquired at ∼24 h and ∼3 months post-injury on mild traumatic brain injury (mTBI; n = 75) and orthopedic injury (n = 60) cohorts. The mTBI subjects were randomly assigned to a treatment group with atorvastatin or a non-treatment mTBI group. The treatment group wa...