Achieving the way for automated segmentation of nuclei in cancer tissue images through morphology-based approach: A quantitative evaluation
Abstract In this paper we address the problem of nuclear segmentation in cancer tissue images, that is critical for specific protein activity quantification and for cancer diagnosis and therapy. We present a fully automated morphology-based technique able to perform accurate nuclear segmentations in...
Saved in:
| Published in | Computerized medical imaging and graphics Vol. 34; no. 6; pp. 453 - 461 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Ltd
01.09.2010
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Abstract In this paper we address the problem of nuclear segmentation in cancer tissue images, that is critical for specific protein activity quantification and for cancer diagnosis and therapy. We present a fully automated morphology-based technique able to perform accurate nuclear segmentations in images with heterogeneous staining and multiple tissue layers and we compare it with an alternate semi-automated method based on a well established segmentation approach, namely active contours. We discuss active contours’ limitations in the segmentation of immunohistochemical images and we demonstrate and motivate through extensive experiments the better accuracy of our fully automated approach compared to various active contours implementations. |
|---|---|
| AbstractList | In this paper we address the problem of nuclear segmentation in cancer tissue images, that is critical for specific protein activity quantification and for cancer diagnosis and therapy. We present a fully automated morphology-based technique able to perform accurate nuclear segmentations in images with heterogeneous staining and multiple tissue layers and we compare it with an alternate semi-automated method based on a well established segmentation approach, namely active contours. We discuss active contours' limitations in the segmentation of immunohistochemical images and we demonstrate and motivate through extensive experiments the better accuracy of our fully automated approach compared to various active contours implementations. Abstract In this paper we address the problem of nuclear segmentation in cancer tissue images, that is critical for specific protein activity quantification and for cancer diagnosis and therapy. We present a fully automated morphology-based technique able to perform accurate nuclear segmentations in images with heterogeneous staining and multiple tissue layers and we compare it with an alternate semi-automated method based on a well established segmentation approach, namely active contours. We discuss active contours’ limitations in the segmentation of immunohistochemical images and we demonstrate and motivate through extensive experiments the better accuracy of our fully automated approach compared to various active contours implementations. |
| Author | Di Cataldo, S Ficarra, E Acquaviva, A Macii, E |
| Author_xml | – sequence: 1 fullname: Di Cataldo, S – sequence: 2 fullname: Ficarra, E – sequence: 3 fullname: Acquaviva, A – sequence: 4 fullname: Macii, E |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20060681$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkkGP0zAQhS20iO0u_AVkTpxSZpI6TjggVRUsSCtxACRuluNMWpfE7tpJUX8Df3oduiDEBXzxwd97Hr03V-zCeUeMvUBYImD5ar80fjgM1NpBb5c5QL3EfAlQPWILrGSdgZR4wRZQ1SIrEfGSXcW4B4AcJD5hl0lSQlnhgv1Ym52lo3VbPu6If9cn3vnA9TT6QY_U8kjbgdyoR-sd9x13k-nJcuu40c5Q4KONcSI-j0IxmQQ_bXd88OGw873fnrJGx-SjD4fgtdm95mt-N2k32tnzSJyOup9-2j9ljzvdR3r2cF-zL-_eft68z24_3nzYrG8zI3A1ZliIpsQVSMi7lRFNK_MWKmE6aoUUushrTY1BgBZl26W8BOqy1qs8naYTbXHNXp5900R3E8VRDTYa6nvtyE9RSVGUlYRC_pssirpKICayPpMm-BgDdeoQUiThpBDUXJraqz9KU3NpCnOVSkva5w-_TE16_6381VICNmeAUipHS0FFYyml39pAZlStt__1zZu_XExvnTW6_0Ynins_BZdiV6hiEqhP8_bMywM1AIrqa3EPSnLHtg |
| CitedBy_id | crossref_primary_10_1016_j_cmpb_2018_08_005 crossref_primary_10_4236_jbise_2013_611128 crossref_primary_10_12688_f1000research_139210_1 crossref_primary_10_1007_s13246_022_01178_4 crossref_primary_10_1111_jmi_12596 crossref_primary_10_1002_jemt_22373 crossref_primary_10_1109_JBHI_2013_2262233 crossref_primary_10_1016_j_compbiomed_2012_08_004 crossref_primary_10_1016_j_compbiomed_2013_10_018 crossref_primary_10_1016_j_bspc_2013_04_003 crossref_primary_10_1186_1746_1596_7_22 crossref_primary_10_1186_1746_1596_8_48 crossref_primary_10_1007_s11760_016_0953_y crossref_primary_10_1007_s10439_010_0103_6 crossref_primary_10_1155_2015_498746 crossref_primary_10_1038_s41598_021_88611_y crossref_primary_10_1016_j_compmedimag_2010_06_001 crossref_primary_10_1016_j_asoc_2016_05_004 |
| Cites_doi | 10.1007/s11263-006-6658-x 10.1093/bioinformatics/btn426 10.1109/83.902291 10.1634/theoncologist.12-4-397 10.1109/TIP.2004.832919 10.1007/BF00133570 10.1109/TITB.2005.847515 10.1117/12.431105 10.1109/TMI.2007.913135 10.1097/00022744-200303000-00014 10.1111/j.1469-7580.2008.00910.x 10.1109/JPROC.2005.845052 10.1109/TIP.2008.2002304 10.1016/0021-9991(88)90002-2 10.3233/FI-2000-411207 10.1109/TITB.2004.828891 10.1109/34.537343 10.1016/S0031-3203(99)00091-6 10.1109/TIP.2003.819858 10.1016/j.jbi.2008.11.005 10.1016/S0165-1684(98)00146-7 10.1023/A:1020878408985 |
| ContentType | Journal Article |
| Copyright | Elsevier Ltd 2009 Elsevier Ltd |
| Copyright_xml | – notice: Elsevier Ltd – notice: 2009 Elsevier Ltd |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 7QO 8FD FR3 P64 |
| DOI | 10.1016/j.compmedimag.2009.12.008 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic Biotechnology Research Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic Engineering Research Database Biotechnology Research Abstracts Technology Research Database Biotechnology and BioEngineering Abstracts |
| DatabaseTitleList | MEDLINE - Academic Engineering Research Database MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1879-0771 |
| EndPage | 461 |
| ExternalDocumentID | 10_1016_j_compmedimag_2009_12_008 20060681 S089561110900158X 1_s2_0_S089561110900158X |
| Genre | Journal Article |
| GroupedDBID | - 0R 1 1- 1B1 1P 1RT 1~. 1~5 29F 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P 9JM 9JN AACTN AAEDT AAIAV AAIKJ AAKOC AALMO AALRI AAOAW AAQFI AAQXK AAXUO ABBOA ABBQC ABFLS ABFNM ABLVK ABMAC ABMZM ABPIF ABPTK ABXDB ABYKQ ACDAQ ACGFS ACIUM ACIWK ACNNM ACPRK ACRLP ACZNC ADALY ADBBV ADEZE ADJOM AEBSH AEKER AENEX AEVXI AFKWA AFRAH AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AHZHX AIALX AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX AOUOD ASPBG AVWKF AZFZN BKOJK BLXMC BNPGV CS3 DC DU5 EBS EFJIC EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FO G- G-2 G-Q GBLVA GBOLZ GJ HEI HLZ HMK HMO HVGLF HZ IHE IPNFZ J1W K KOM LCYCR LX9 M M29 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SBC SDF SDG SDP SEL SES SEW SPC SPCBC SSH SSV SSZ T5K WUQ Z5R ZGI --- --K --M .1- .DC .FO .GJ .~1 0R~ 1P~ 8P~ AAEDW AAYFN ABJNI ADMUD AXJTR EFLBG FYGXN HZ~ ~G- AAXKI AFCTW AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 7QO 8FD FR3 P64 |
| ID | FETCH-LOGICAL-c514t-135b6140702f4c5bd72d085cfed575a329aebc100d17df01651a69a42222bf5d3 |
| IEDL.DBID | AIKHN |
| ISSN | 0895-6111 |
| IngestDate | Fri Aug 16 22:02:21 EDT 2024 Fri Aug 16 07:17:37 EDT 2024 Thu Sep 26 15:31:53 EDT 2024 Sat Sep 28 07:58:37 EDT 2024 Fri Feb 23 02:19:32 EST 2024 Thu Aug 18 18:35:30 EDT 2022 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | Immunohistochemistry Morphological operators Nuclear segmentation Tissue images Active contours |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c514t-135b6140702f4c5bd72d085cfed575a329aebc100d17df01651a69a42222bf5d3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| OpenAccessLink | https://iris.polito.it/bitstream/11583/2294987/1/draftCMIG_2011_PORTO.pdf |
| PMID | 20060681 |
| PQID | 733980371 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_753687037 proquest_miscellaneous_733980371 crossref_primary_10_1016_j_compmedimag_2009_12_008 pubmed_primary_20060681 elsevier_sciencedirect_doi_10_1016_j_compmedimag_2009_12_008 elsevier_clinicalkeyesjournals_1_s2_0_S089561110900158X |
| PublicationCentury | 2000 |
| PublicationDate | 2010-09-01 |
| PublicationDateYYYYMMDD | 2010-09-01 |
| PublicationDate_xml | – month: 09 year: 2010 text: 2010-09-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Computerized medical imaging and graphics |
| PublicationTitleAlternate | Comput Med Imaging Graph |
| PublicationYear | 2010 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Xu (bib37) 2000 Hengerer (bib1) 2005; 93 Couture R. Jacob (bib32) 2004; 13 Tukey (bib44) 1977 Elmoataz (bib8) 1998; 71 Ruifrok (bib17) 2004; 11 Di Cataldo (bib22) 2007 Garrido (bib9) 2000; 33 Nattkemper (bib20) 2004 McInerney (bib25) 1993; 15 Jacob M. Milstei (bib21) 1998 Caselles (bib33) 1995 Ruifrok (bib16) 2001; 23 Lejeune (bib12) 2008; 212 Chang (bib13) 2009; 25 Zhu (bib39) 1996; 18 Landini G. Software; October 2007. Li (bib36) 2008; 17 Jrgensena (bib4) 2007; 12 Chen (bib27) 2002; 50 Mukherjee (bib7) 2004; 13 Leventon (bib26) 2000; 1 Huang (bib29) 2002 Chen (bib2) 2004; 8 Diaz (bib15) 2009; 42 Roerdink (bib23) 2001; 41 Bresson (bib30) 2006; 68 Rousson (bib28) 2002 Chan (bib34) 2001; 10 Ling Pi (bib10) 2006; 27 McCullough (bib14) 2008; 27 . Rasband WS. ImageJ. Bethesda, MD, USA: U.S. National Institutes of Health. Paragios (bib38) 1999 Di Cataldo (bib11) 2008 Ficarra (bib5) 2006 Osher (bib35) 1988; 79 Jacob (bib31) 2001; 4322 Taneja (bib3) 2004; 2 Yang (bib6) 2005; 9 Ridler (bib19) 1978 Kass (bib24) 1987; 1 Di Cataldo (10.1016/j.compmedimag.2009.12.008_bib11) 2008 McInerney (10.1016/j.compmedimag.2009.12.008_bib25) 1993; 15 Ruifrok (10.1016/j.compmedimag.2009.12.008_bib17) 2004; 11 Caselles (10.1016/j.compmedimag.2009.12.008_bib33) 1995 Yang (10.1016/j.compmedimag.2009.12.008_bib6) 2005; 9 Jacob (10.1016/j.compmedimag.2009.12.008_bib32) 2004; 13 McCullough (10.1016/j.compmedimag.2009.12.008_bib14) 2008; 27 10.1016/j.compmedimag.2009.12.008_bib18 Jacob (10.1016/j.compmedimag.2009.12.008_bib31) 2001; 4322 Kass (10.1016/j.compmedimag.2009.12.008_bib24) 1987; 1 Hengerer (10.1016/j.compmedimag.2009.12.008_bib1) 2005; 93 Diaz (10.1016/j.compmedimag.2009.12.008_bib15) 2009; 42 Chan (10.1016/j.compmedimag.2009.12.008_bib34) 2001; 10 Bresson (10.1016/j.compmedimag.2009.12.008_bib30) 2006; 68 Lejeune (10.1016/j.compmedimag.2009.12.008_bib12) 2008; 212 Zhu (10.1016/j.compmedimag.2009.12.008_bib39) 1996; 18 Milstei (10.1016/j.compmedimag.2009.12.008_bib21) 1998 Chang (10.1016/j.compmedimag.2009.12.008_bib13) 2009; 25 Nattkemper (10.1016/j.compmedimag.2009.12.008_bib20) 2004 Xu (10.1016/j.compmedimag.2009.12.008_bib37) 2000 Rousson (10.1016/j.compmedimag.2009.12.008_bib28) 2002 Jrgensena (10.1016/j.compmedimag.2009.12.008_bib4) 2007; 12 Chen (10.1016/j.compmedimag.2009.12.008_bib27) 2002; 50 Roerdink (10.1016/j.compmedimag.2009.12.008_bib23) 2001; 41 Ficarra (10.1016/j.compmedimag.2009.12.008_bib5) 2006 Paragios (10.1016/j.compmedimag.2009.12.008_bib38) 1999 Osher (10.1016/j.compmedimag.2009.12.008_bib35) 1988; 79 Ruifrok (10.1016/j.compmedimag.2009.12.008_bib16) 2001; 23 Mukherjee (10.1016/j.compmedimag.2009.12.008_bib7) 2004; 13 Garrido (10.1016/j.compmedimag.2009.12.008_bib9) 2000; 33 Taneja (10.1016/j.compmedimag.2009.12.008_bib3) 2004; 2 Ridler (10.1016/j.compmedimag.2009.12.008_bib19) 1978 Ling Pi (10.1016/j.compmedimag.2009.12.008_bib10) 2006; 27 Leventon (10.1016/j.compmedimag.2009.12.008_bib26) 2000; 1 Elmoataz (10.1016/j.compmedimag.2009.12.008_bib8) 1998; 71 10.1016/j.compmedimag.2009.12.008_bib45 10.1016/j.compmedimag.2009.12.008_bib43 Di Cataldo (10.1016/j.compmedimag.2009.12.008_bib22) 2007 10.1016/j.compmedimag.2009.12.008_bib42 Li (10.1016/j.compmedimag.2009.12.008_bib36) 2008; 17 10.1016/j.compmedimag.2009.12.008_bib41 Huang (10.1016/j.compmedimag.2009.12.008_bib29) 2002 10.1016/j.compmedimag.2009.12.008_bib40 Chen (10.1016/j.compmedimag.2009.12.008_bib2) 2004; 8 Tukey (10.1016/j.compmedimag.2009.12.008_bib44) 1977 |
| References_xml | – volume: 33 start-page: 821 year: 2000 end-page: 832 ident: bib9 article-title: Applying deformable templates for cell image segmentation publication-title: Pattern Recogn contributor: fullname: Garrido – start-page: 630 year: 1978 end-page: 632 ident: bib19 article-title: Picture thresholding using an iterative selection method publication-title: IEEE T Syst M Cy, SMC-8 contributor: fullname: Ridler – volume: 27 start-page: 723 year: 2008 end-page: 734 ident: bib14 article-title: Segmentation of whole cells and cell nuclei from 3-D optical microscope images using dynamic programming publication-title: IEEE Trans Med Imag contributor: fullname: McCullough – start-page: 483 year: 2000 end-page: 489 ident: bib37 article-title: On the relationship between parametric and geometric active contours publication-title: Proceedings of Asilomar’00 contributor: fullname: Xu – volume: 15 start-page: 580 year: 1993 end-page: 591 ident: bib25 article-title: Deformable models in medical image analysis: a survey publication-title: Med Imag Anal contributor: fullname: McInerney – volume: 212 start-page: 868 year: 2008 end-page: 878 ident: bib12 article-title: Quantification of diverse subcellular immunohistochemical markers with clinicobiological relevancies: validation of a new computer-assisted image analysis procedure publication-title: J Anat contributor: fullname: Lejeune – volume: 41 start-page: 187 year: 2001 end-page: 228 ident: bib23 article-title: The watershed transform: definitions, algorithms and parallelization strategies publication-title: Fund Inform contributor: fullname: Roerdink – volume: 13 start-page: 1231 year: 2004 end-page: 1244 ident: bib32 article-title: Efficient energies and algorithms for parametric snakes publication-title: IEEE T Imag Process contributor: fullname: Jacob – volume: 17 start-page: 1940 year: 2008 end-page: 1949 ident: bib36 article-title: Minimization of region-scalable fitting energy for image segmentation publication-title: IEEE T Imag Process contributor: fullname: Li – start-page: 413 year: 2006 end-page: 418 ident: bib5 article-title: Computer-aided evaluation of protein expression in pathological tissue images publication-title: Proceedings of CBMS’06 contributor: fullname: Ficarra – volume: 4322 start-page: 340 year: 2001 end-page: 347 ident: bib31 article-title: A unifying approach and interface for spline-based snakes publication-title: Proc SPIE MI contributor: fullname: Jacob – volume: 93 year: 2005 ident: bib1 article-title: From genomics to clinical molecular imaging publication-title: Proc IEEE contributor: fullname: Hengerer – volume: 27 start-page: 51 year: 2006 end-page: 57 ident: bib10 article-title: Color image segmentation for objects of interest with modified geodesic active contour method publication-title: J Math Imag Vis contributor: fullname: Ling Pi – volume: 79 start-page: 12 year: 1988 end-page: 49 ident: bib35 article-title: Fronts propagating with curvature-dependent speed: algorithms based on Hamilton–Jacobi formulations publication-title: J Comput Phys contributor: fullname: Osher – start-page: 1 year: 2008 end-page: 6 ident: bib11 article-title: Segmentation of nuclei in cancer tissue images: contrasting active contours with morphology-based approach publication-title: Proceedings of BIBE2008 contributor: fullname: Di Cataldo – volume: 12 start-page: 397 year: 2007 end-page: 405 ident: bib4 article-title: Pharmacodiagnostics and targeted therapies a rational approach for individualizing medical anticancer therapy in breast cancer publication-title: Oncologist contributor: fullname: Jrgensena – volume: 11 start-page: 85 year: 2004 end-page: 91 ident: bib17 article-title: Comparison of quantification of histochemical staining by Hue-Saturation-Intensity (HSI) transformation and color deconvolution publication-title: Appl Immunohistochem Mol Morphol contributor: fullname: Ruifrok – volume: 18 start-page: 884 year: 1996 end-page: 900 ident: bib39 article-title: Region competition: unifying snakes, region growing, and Bayes/MDL for multiband image segmentation publication-title: IEEE T PAMI contributor: fullname: Zhu – volume: 13 start-page: 562 year: 2004 end-page: 572 ident: bib7 article-title: Level set analysis for leukocyte detection and tracking publication-title: IEEE T Image Process contributor: fullname: Mukherjee – volume: 23 start-page: 291 year: 2001 end-page: 299 ident: bib16 article-title: Quantification of histochemical staining by color deconvolution publication-title: Anal Quant Cytol Histol contributor: fullname: Ruifrok – start-page: 390 year: 2007 end-page: 398 ident: bib22 article-title: Selection of tumor areas and segmentation of nuclear membranes in tissue confocal images: a fully automated approach publication-title: Proceedings of BIBM’07 contributor: fullname: Di Cataldo – volume: 10 start-page: 266 year: 2001 end-page: 276 ident: bib34 article-title: Active contours without edges publication-title: IEEE T Imag Process contributor: fullname: Chan – volume: 2 year: 2004 ident: bib3 article-title: Markers of small cell lung cancer publication-title: World J Surg Oncol contributor: fullname: Taneja – start-page: 300 year: 1999 end-page: 305 ident: bib38 article-title: Unyfing boundary and region-based information for geodesic active tracking publication-title: Proceedings of IEEE CVPR contributor: fullname: Paragios – volume: 1 start-page: 321 year: 1987 end-page: 331 ident: bib24 article-title: Snakes: active contours models publication-title: Int J Comp Vis contributor: fullname: Kass – start-page: 694 year: 1995 end-page: 699 ident: bib33 article-title: Geodesic active contours publication-title: Proceedings of 5th International Conference on Computer Vision contributor: fullname: Caselles – volume: 71 start-page: 215 year: 1998 end-page: 226 ident: bib8 article-title: Using active contours and mathematical morphology tools for quantification of immunohistochemical images publication-title: Signal Process contributor: fullname: Elmoataz – volume: 25 start-page: 1070 year: 2009 end-page: 1075 ident: bib13 article-title: Graphical methods for quantifying macromolecules through bright field imaging publication-title: Bioinformatics contributor: fullname: Chang – year: 1977 ident: bib44 article-title: Exploratory data analysis contributor: fullname: Tukey – volume: 42 start-page: 296 year: 2009 end-page: 307 ident: bib15 article-title: A semi-automatic method for quantification and classification of erythrocytes infected with malaria parasites in microscopic images publication-title: J Biomed Inform contributor: fullname: Diaz – volume: 50 start-page: 315 year: 2002 end-page: 328 ident: bib27 article-title: Using prior shapes in geometric active contours in a variational framework publication-title: IJCV contributor: fullname: Chen – start-page: 847 year: 2004 end-page: 851 ident: bib20 article-title: Automatic segmentation of digital micrographs: a survey publication-title: Proceedings of MEDINFO’04, vol. 11(Pt 2) contributor: fullname: Nattkemper – volume: 8 start-page: 89 year: 2004 end-page: 96 ident: bib2 article-title: Unsupervised tissue microarray analysis for cancer research and diagnostics publication-title: IEEE T Inf Technol B contributor: fullname: Chen – volume: 1 start-page: 316 year: 2000 end-page: 323 ident: bib26 article-title: Statistical shape influence in geodesic active contours publication-title: Proc CVPR’00 contributor: fullname: Leventon – start-page: 1 year: 1998 end-page: 38 ident: bib21 article-title: Image segmentation through adaptive thresholding publication-title: Technion – Israel Inst Technol contributor: fullname: Milstei – start-page: 2090 year: 2002 end-page: 2093 ident: bib29 article-title: Face contour detection using geometric active contours publication-title: Proceedings of WCICA’04 contributor: fullname: Huang – volume: 9 start-page: 475 year: 2005 end-page: 486 ident: bib6 article-title: Unsupervised segmentation based on robust estimation and color active contour models publication-title: IEEE T Inf Tech B contributor: fullname: Yang – start-page: 78 year: 2002 end-page: 92 ident: bib28 article-title: Shape priors for level set representations publication-title: Proceedings of ECCV contributor: fullname: Rousson – volume: 68 start-page: 145 year: 2006 end-page: 162 ident: bib30 article-title: A variational model for object segmentation using boundary information and shape driven by the Mumford–Shah functional publication-title: IJCV contributor: fullname: Bresson – volume: 68 start-page: 145 issue: 2 year: 2006 ident: 10.1016/j.compmedimag.2009.12.008_bib30 article-title: A variational model for object segmentation using boundary information and shape driven by the Mumford–Shah functional publication-title: IJCV doi: 10.1007/s11263-006-6658-x contributor: fullname: Bresson – ident: 10.1016/j.compmedimag.2009.12.008_bib41 – volume: 25 start-page: 1070 issue: 8 year: 2009 ident: 10.1016/j.compmedimag.2009.12.008_bib13 article-title: Graphical methods for quantifying macromolecules through bright field imaging publication-title: Bioinformatics doi: 10.1093/bioinformatics/btn426 contributor: fullname: Chang – start-page: 2090 year: 2002 ident: 10.1016/j.compmedimag.2009.12.008_bib29 article-title: Face contour detection using geometric active contours contributor: fullname: Huang – start-page: 1 year: 1998 ident: 10.1016/j.compmedimag.2009.12.008_bib21 article-title: Image segmentation through adaptive thresholding publication-title: Technion – Israel Inst Technol contributor: fullname: Milstei – volume: 10 start-page: 266 year: 2001 ident: 10.1016/j.compmedimag.2009.12.008_bib34 article-title: Active contours without edges publication-title: IEEE T Imag Process doi: 10.1109/83.902291 contributor: fullname: Chan – volume: 12 start-page: 397 issue: 4 year: 2007 ident: 10.1016/j.compmedimag.2009.12.008_bib4 article-title: Pharmacodiagnostics and targeted therapies a rational approach for individualizing medical anticancer therapy in breast cancer publication-title: Oncologist doi: 10.1634/theoncologist.12-4-397 contributor: fullname: Jrgensena – volume: 15 start-page: 580 issue: 6 year: 1993 ident: 10.1016/j.compmedimag.2009.12.008_bib25 article-title: Deformable models in medical image analysis: a survey publication-title: Med Imag Anal contributor: fullname: McInerney – volume: 13 start-page: 1231 issue: 9 year: 2004 ident: 10.1016/j.compmedimag.2009.12.008_bib32 article-title: Efficient energies and algorithms for parametric snakes publication-title: IEEE T Imag Process doi: 10.1109/TIP.2004.832919 contributor: fullname: Jacob – ident: 10.1016/j.compmedimag.2009.12.008_bib18 – volume: 1 start-page: 321 issue: 4 year: 1987 ident: 10.1016/j.compmedimag.2009.12.008_bib24 article-title: Snakes: active contours models publication-title: Int J Comp Vis doi: 10.1007/BF00133570 contributor: fullname: Kass – start-page: 1 year: 2008 ident: 10.1016/j.compmedimag.2009.12.008_bib11 article-title: Segmentation of nuclei in cancer tissue images: contrasting active contours with morphology-based approach contributor: fullname: Di Cataldo – year: 1977 ident: 10.1016/j.compmedimag.2009.12.008_bib44 contributor: fullname: Tukey – start-page: 483 year: 2000 ident: 10.1016/j.compmedimag.2009.12.008_bib37 article-title: On the relationship between parametric and geometric active contours contributor: fullname: Xu – volume: 9 start-page: 475 issue: 3 year: 2005 ident: 10.1016/j.compmedimag.2009.12.008_bib6 article-title: Unsupervised segmentation based on robust estimation and color active contour models publication-title: IEEE T Inf Tech B doi: 10.1109/TITB.2005.847515 contributor: fullname: Yang – start-page: 390 year: 2007 ident: 10.1016/j.compmedimag.2009.12.008_bib22 article-title: Selection of tumor areas and segmentation of nuclear membranes in tissue confocal images: a fully automated approach contributor: fullname: Di Cataldo – volume: 23 start-page: 291 issue: 4 year: 2001 ident: 10.1016/j.compmedimag.2009.12.008_bib16 article-title: Quantification of histochemical staining by color deconvolution publication-title: Anal Quant Cytol Histol contributor: fullname: Ruifrok – volume: 4322 start-page: 340 year: 2001 ident: 10.1016/j.compmedimag.2009.12.008_bib31 article-title: A unifying approach and interface for spline-based snakes publication-title: Proc SPIE MI doi: 10.1117/12.431105 contributor: fullname: Jacob – volume: 1 start-page: 316 year: 2000 ident: 10.1016/j.compmedimag.2009.12.008_bib26 article-title: Statistical shape influence in geodesic active contours publication-title: Proc CVPR’00 contributor: fullname: Leventon – volume: 27 start-page: 723 issue: 5 year: 2008 ident: 10.1016/j.compmedimag.2009.12.008_bib14 article-title: Segmentation of whole cells and cell nuclei from 3-D optical microscope images using dynamic programming publication-title: IEEE Trans Med Imag doi: 10.1109/TMI.2007.913135 contributor: fullname: McCullough – volume: 11 start-page: 85 issue: 1 year: 2004 ident: 10.1016/j.compmedimag.2009.12.008_bib17 article-title: Comparison of quantification of histochemical staining by Hue-Saturation-Intensity (HSI) transformation and color deconvolution publication-title: Appl Immunohistochem Mol Morphol doi: 10.1097/00022744-200303000-00014 contributor: fullname: Ruifrok – start-page: 413 year: 2006 ident: 10.1016/j.compmedimag.2009.12.008_bib5 article-title: Computer-aided evaluation of protein expression in pathological tissue images contributor: fullname: Ficarra – volume: 212 start-page: 868 issue: 6 year: 2008 ident: 10.1016/j.compmedimag.2009.12.008_bib12 article-title: Quantification of diverse subcellular immunohistochemical markers with clinicobiological relevancies: validation of a new computer-assisted image analysis procedure publication-title: J Anat doi: 10.1111/j.1469-7580.2008.00910.x contributor: fullname: Lejeune – ident: 10.1016/j.compmedimag.2009.12.008_bib43 – volume: 93 issue: 4 year: 2005 ident: 10.1016/j.compmedimag.2009.12.008_bib1 article-title: From genomics to clinical molecular imaging publication-title: Proc IEEE doi: 10.1109/JPROC.2005.845052 contributor: fullname: Hengerer – start-page: 847 year: 2004 ident: 10.1016/j.compmedimag.2009.12.008_bib20 article-title: Automatic segmentation of digital micrographs: a survey contributor: fullname: Nattkemper – volume: 17 start-page: 1940 issue: 10 year: 2008 ident: 10.1016/j.compmedimag.2009.12.008_bib36 article-title: Minimization of region-scalable fitting energy for image segmentation publication-title: IEEE T Imag Process doi: 10.1109/TIP.2008.2002304 contributor: fullname: Li – ident: 10.1016/j.compmedimag.2009.12.008_bib45 – ident: 10.1016/j.compmedimag.2009.12.008_bib42 – start-page: 78 year: 2002 ident: 10.1016/j.compmedimag.2009.12.008_bib28 article-title: Shape priors for level set representations contributor: fullname: Rousson – volume: 79 start-page: 12 year: 1988 ident: 10.1016/j.compmedimag.2009.12.008_bib35 article-title: Fronts propagating with curvature-dependent speed: algorithms based on Hamilton–Jacobi formulations publication-title: J Comput Phys doi: 10.1016/0021-9991(88)90002-2 contributor: fullname: Osher – start-page: 630 year: 1978 ident: 10.1016/j.compmedimag.2009.12.008_bib19 article-title: Picture thresholding using an iterative selection method publication-title: IEEE T Syst M Cy, SMC-8 contributor: fullname: Ridler – volume: 41 start-page: 187 year: 2001 ident: 10.1016/j.compmedimag.2009.12.008_bib23 article-title: The watershed transform: definitions, algorithms and parallelization strategies publication-title: Fund Inform doi: 10.3233/FI-2000-411207 contributor: fullname: Roerdink – volume: 8 start-page: 89 issue: 2 year: 2004 ident: 10.1016/j.compmedimag.2009.12.008_bib2 article-title: Unsupervised tissue microarray analysis for cancer research and diagnostics publication-title: IEEE T Inf Technol B doi: 10.1109/TITB.2004.828891 contributor: fullname: Chen – volume: 27 start-page: 51 issue: 1 year: 2006 ident: 10.1016/j.compmedimag.2009.12.008_bib10 article-title: Color image segmentation for objects of interest with modified geodesic active contour method publication-title: J Math Imag Vis contributor: fullname: Ling Pi – volume: 18 start-page: 884 year: 1996 ident: 10.1016/j.compmedimag.2009.12.008_bib39 article-title: Region competition: unifying snakes, region growing, and Bayes/MDL for multiband image segmentation publication-title: IEEE T PAMI doi: 10.1109/34.537343 contributor: fullname: Zhu – start-page: 300 year: 1999 ident: 10.1016/j.compmedimag.2009.12.008_bib38 article-title: Unyfing boundary and region-based information for geodesic active tracking contributor: fullname: Paragios – volume: 33 start-page: 821 issue: 5 year: 2000 ident: 10.1016/j.compmedimag.2009.12.008_bib9 article-title: Applying deformable templates for cell image segmentation publication-title: Pattern Recogn doi: 10.1016/S0031-3203(99)00091-6 contributor: fullname: Garrido – volume: 2 issue: 10 year: 2004 ident: 10.1016/j.compmedimag.2009.12.008_bib3 article-title: Markers of small cell lung cancer publication-title: World J Surg Oncol contributor: fullname: Taneja – volume: 13 start-page: 562 issue: 4 year: 2004 ident: 10.1016/j.compmedimag.2009.12.008_bib7 article-title: Level set analysis for leukocyte detection and tracking publication-title: IEEE T Image Process doi: 10.1109/TIP.2003.819858 contributor: fullname: Mukherjee – volume: 42 start-page: 296 issue: 2 year: 2009 ident: 10.1016/j.compmedimag.2009.12.008_bib15 article-title: A semi-automatic method for quantification and classification of erythrocytes infected with malaria parasites in microscopic images publication-title: J Biomed Inform doi: 10.1016/j.jbi.2008.11.005 contributor: fullname: Diaz – volume: 71 start-page: 215 issue: 2 year: 1998 ident: 10.1016/j.compmedimag.2009.12.008_bib8 article-title: Using active contours and mathematical morphology tools for quantification of immunohistochemical images publication-title: Signal Process doi: 10.1016/S0165-1684(98)00146-7 contributor: fullname: Elmoataz – volume: 50 start-page: 315 issue: 3 year: 2002 ident: 10.1016/j.compmedimag.2009.12.008_bib27 article-title: Using prior shapes in geometric active contours in a variational framework publication-title: IJCV doi: 10.1023/A:1020878408985 contributor: fullname: Chen – start-page: 694 year: 1995 ident: 10.1016/j.compmedimag.2009.12.008_bib33 article-title: Geodesic active contours contributor: fullname: Caselles – ident: 10.1016/j.compmedimag.2009.12.008_bib40 |
| SSID | ssj0002071 |
| Score | 2.0953858 |
| Snippet | Abstract In this paper we address the problem of nuclear segmentation in cancer tissue images, that is critical for specific protein activity quantification... In this paper we address the problem of nuclear segmentation in cancer tissue images, that is critical for specific protein activity quantification and for... |
| SourceID | proquest crossref pubmed elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 453 |
| SubjectTerms | Active contours Cell Nucleus - diagnostic imaging Connective Tissue - diagnostic imaging Connective Tissue - pathology Diagnostic Imaging - methods Humans Image Processing, Computer-Assisted - methods Immunohistochemistry Internal Medicine Morphological operators Neoplasms - diagnostic imaging Nuclear segmentation Other Radiography Tissue images |
| Title | Achieving the way for automated segmentation of nuclei in cancer tissue images through morphology-based approach: A quantitative evaluation |
| URI | https://www.clinicalkey.es/playcontent/1-s2.0-S089561110900158X https://dx.doi.org/10.1016/j.compmedimag.2009.12.008 https://www.ncbi.nlm.nih.gov/pubmed/20060681 https://search.proquest.com/docview/733980371 https://search.proquest.com/docview/753687037 |
| Volume | 34 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB61W6nignizBapB4ho2zssJ4rKqqBZQe4FKe7Ps2CmptElpdoV64Q_wp5lJnC2Ih5C4RrbieOxvvswT4EVihJausIGtiiJInC0IBzMdJFHpQi3ivOo9-Cen2eIsebdMlztwNObCcFilx_4B03u09k9mfjdnl3U9-xDmnJTJFTNZ8efLXdgjdZQkE9ibv32_ON0CchT2_108PuAJ-_D8JsyLI7fZjb3S50P1SjYOcrPJ36upP9HQXh0d34HbnkfifFjqXdhxzT3YP_Ge8vvwbV5-qh1bC5AoHn7R10j0FPVm3RJHdRY7d77yeUcNthU2XNi4xrrBkg_CFa57kSAv2XXo-_ngqiXB9Kb4gBWgxbEo-Suc4-eNbvqkNYJQvKkj_gDOjt98PFoEvvFCUBJ_4vb0qSG1TWgQVUmZGisjS9SsrJwldqfjqNDOlCIMrZC24oQoobNCszUpMlVq44cwadrGPQY0WoaiioVLtE1SKYyRTptMktiIalV6CtG4z-pyqK-hxsCzC_WDcLhfZqFEpEg4U5CjRNSYQEqQ5zp__zolVEcj1S9nZAqvtzN_OmaKNMi_vBhH-Su6huxb0Y1rN52ScVzkXP7wL0PSOCN0jOUUHg1HZ_vFbNcJs1wc_N_ynsCtIbiBQ-CewmR9tXHPiDOtzSHsvvwqDv3N-A6f2Bni |
| link.rule.ids | 315,786,790,4521,24144,27957,27958,45620,45714 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB6VrVS4IN4sz0HiGm2clzeIy6qi2tLuXmilvVl27JQgbVKaXSF-A3-amcTZgngIiWtkK47H_ubLPAFeJ0Zo6XIb2DLPg8TZnHAw00ESFS7UIp6WnQd_sczm58n7Vbrag8MhF4bDKj3295jeobV_MvG7ObmsqsmHcMpJmVwxkxX_dHUD9pNUimQE-7Pjk_lyB8hR2P138fiAJxzAq-swL47cZjf2Wl_01SvZOMjNJn-vpv5EQzt1dHQHbnseibN-qXdhz9X34GDhPeX34dus-Fg5thYgUTz8or8i0VPU201DHNVZbN3F2ucd1diUWHNh4wqrGgs-CFe46USCvGTXou_ng-uGBNOZ4gNWgBaHouRvcIaft7ruktYIQvG6jvgDOD96d3Y4D3zjhaAg_sTt6VNDapvQICqTIjVWRpaoWVE6S-xOx1GunSlEGFohbckJUUJnuWZrUmTK1MYPYVQ3tXsMaLQMRRkLl2jL0jFGOm0ySWIjqlXqMUTDPqvLvr6GGgLPPqkfhMP9MnMlIkXCGYMcJKKGBFKCPNf6-9cqoVoaqX45I2N4u5v50zFTpEH-5cU4yF_RNWTfiq5ds22VjON8yuUP_zIkjTNCx1iO4VF_dHZfzHadMJuKJ_-3vJdwc362OFWnx8uTp3CrD3TgcLhnMNpcbd1z4k8b88Lfj-9nNBvU |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Achieving+the+way+for+automated+segmentation+of+nuclei+in+cancer+tissue+images+through+morphology-based+approach%3A+A+quantitative+evaluation&rft.jtitle=Computerized+medical+imaging+and+graphics&rft.au=Di+Cataldo%2C+S.&rft.au=Ficarra%2C+E.&rft.au=Acquaviva%2C+A.&rft.au=Macii%2C+E.&rft.date=2010-09-01&rft.issn=0895-6111&rft.volume=34&rft.issue=6&rft.spage=453&rft.epage=461&rft_id=info:doi/10.1016%2Fj.compmedimag.2009.12.008&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_compmedimag_2009_12_008 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F08956111%2FS0895611110X00064%2Fcov150h.gif |