Minor salivary gland tumors of the head and neck—Memorial Sloan Kettering experience: Incidence and outcomes by site and histological type

• Published in: Cancer Vol. 125; no. 19; pp. 3354 - 3366
• Main Authors: Hay, Ashley J., Migliacci, Jocelyn, Karassawa Zanoni, Daniella, McGill, Marlena, Patel, Snehal, Ganly, Ian
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.10.2019
• Subjects: Adenocarcinoma; Adenoid; Adolescent; Adult; Aged; Aged, 80 and over; Cancer; Carcinoma, Mucoepidermoid - epidemiology; Carcinoma, Mucoepidermoid - pathology; Disease-Free Survival; Female; Follow-Up Studies; Head & neck cancer; Head and neck; head and neck cancer; Head and neck carcinoma; Humans; Incidence; Larynx; Male; Margins of Excision; Mathematical analysis; Middle Aged; minor salivary gland carcinoma; Multivariate analysis; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - prevention & control; Neoplasm Staging; Oncology; Oral cancer; Oral cavity; Oropharynx; outcomes; Pathology; Patients; prediction; Prognosis; Radiation therapy; Radiotherapy, Adjuvant; Regression analysis; Retrospective Studies; Salivary gland; Salivary Gland Neoplasms - epidemiology; Salivary Gland Neoplasms - pathology; Salivary Gland Neoplasms - therapy; Salivary glands; Salivary Glands, Minor - pathology; Salivary Glands, Minor - radiation effects; Salivary Glands, Minor - surgery; Statistical analysis; Survival; Survival Rate; Trachea; Tumors; United States - epidemiology; Variables; Young Adult; United States; prediction; head and neck cancer; minor salivary gland carcinoma; outcomes; survival
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/cncr.32208

Background Minor salivary gland carcinomas of the head and neck are rare cancers with variable clinical behavior. This study explored the incidence, pathology, clinical behavior, and factors predictive of outcomes in a large cohort of patients treated at Memorial Sloan Kettering Cancer Center over a 30‐year period (1985‐2015). Methods Clinical, pathological, treatment, and outcome data were collected. Unadjusted and adjusted hazard ratios for each variable were calculated with univariate and multivariable Cox regression for survival and recurrence outcomes. Results Four hundred fifty patients were included: 55% were female, 56% were younger than 60 years, and the median follow‐up was 74 months (range, 1‐364 months). The most common site was the oral cavity with 305 tumors (68%), which was followed by the oropharynx with 96 (21%), the sinonasal cavity with 38 (8%), the trachea with 7 (2%), and the larynx with 4 (1%). The most common histological types were mucoepidermoid carcinoma (180 tumors [40%]), adenoid cystic carcinoma (141 tumors [31%]), and polymorphous low‐grade adenocarcinoma (54 tumors [12%]). The 5‐year predicted overall survival rate was 86%, and the disease‐specific survival rate was 94% at 5 years. Pathology and tumor stage were significant variables on multivariate analysis for overall survival, disease‐specific survival, recurrence‐free survival, local recurrence–free survival, regional recurrence–free survival, and distant recurrence–free survival. Conclusions American Joint Committee on Cancer stage and pathology were the most predictive variables across all outcomes. Tumor site, postoperative radiotherapy, and margin status were not statistically significant variables after tumor stage and pathology were controlled for in most outcomes. This is a large retrospective study of 450 minor salivary gland tumors of the head and neck. The tumor stage and histological type are the most predictive variables of survival and recurrence.