Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension

BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hyper...

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Bibliographic Details
Published inPulmonary circulation Vol. 12; no. 1; pp. e12056 - n/a
Main Authors Liu, Bin, Yi, Dan, Pan, Jiakai, Dai, Jingbo, Zhu, Maggie M., Zhao, You‐Yang, Oh, S. Paul, Fallon, Michael B., Dai, Zhiyu
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.01.2022
John Wiley and Sons Inc
Wiley
Subjects
angiogenesis
BMPR2
hypoxia
pulmonary hypertension
Research Letter
hypoxia
BMPR2
angiogenesis
pulmonary hypertension
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Summary:BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2045-8940
2045-8932
2045-8940
DOI:10.1002/pul2.12056