Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus

• Published in: Glia Vol. 67; no. 8; pp. 1434 - 1448
• Main Authors: Feng, Lijie, Murugan, Madhuvika, Bosco, Dale B., Liu, Yong, Peng, Jiyun, Worrell, Gregory A., Wang, Hai‐Long, Ta, Lauren E., Richardson, Jason R., Shen, Yuxian, Wu, Long‐Jun
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.08.2019; Wiley Subscription Services, Inc
• Subjects: Animals; Attenuation; Brain; Calcium-Binding Proteins - metabolism; CC chemokine receptors; CCR2 protein; Cell activation; Cell Death; Cell Proliferation; Cerebrospinal fluid; colony stimulating factor 1 receptor; Convulsions & seizures; CX3C Chemokine Receptor 1 - genetics; CX3C Chemokine Receptor 1 - metabolism; CX3CR1 protein; Disease Models, Animal; Epilepsy; Gliosis - etiology; Gliosis - physiopathology; Hippocampus; Hippocampus - physiopathology; Infiltration; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins - metabolism; Microglia; Microglia - physiology; Monocyte chemoattractant protein 1; Monocytes; Monocytes - physiology; Neuroimaging; Neurons - physiology; Neuroprotection; Pharmacology; Physical characteristics; proliferation; Receptor, Macrophage Colony-Stimulating Factor - metabolism; Receptors, CCR2 - genetics; Receptors, CCR2 - metabolism; Recording; Seizures; Status Epilepticus - complications; Status Epilepticus - physiopathology; Therapeutic applications; Tissue Culture Techniques; epilepsy; monocytes; colony stimulating factor 1 receptor; proliferation; microglia; infiltration

Microglial activation has been recognized as a major contributor to inflammation of the epileptic brain. Seizures are commonly accompanied by remarkable microgliosis and loss of neurons. In this study, we utilize the CX3CR1GFP/+ CCR2RFP/+ genetic mouse model, in which CX3CR1+ resident microglia and...