LINC00473‐modified bone marrow mesenchymal stem cells incorporated thermosensitive PLGA hydrogel transplantation for steroid‐induced osteonecrosis of femoral head: A detailed mechanistic study and validity evaluation

• Published in: Bioengineering & translational medicine Vol. 7; no. 2; pp. e10275 - n/a
• Main Authors: Xu, Yingxing, Jiang, Yaping, Wang, Yingzhen, Jia, Bin, Gao, Song, Yu, Haiyang, Zhang, Haining, Lv, Chengyu, Li, Haiyan, Li, Tao
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2022; Wiley
• Subjects: Apoptosis; Binding sites; Bioinformatics; Biomedical materials; Bone marrow; bone marrow mesenchymal stem cells; Cancer; Cell cycle; cell therapy; Dexamethasone; Differentiation; Gene expression; Glucocorticoids; Glycolic acid; Hydrogels; LncRNA LINC00473; Low density lipoprotein receptors; MicroRNAs; Osteonecrosis; osteonecrosis of femoral head; Pathogenesis; Proteins; Ribonucleic acid; RNA; Signaling; Stem cells; Steroids; Tissue engineering; Transplantation; hydrogels; bone marrow mesenchymal stem cells; LncRNA LINC00473; cell therapy; osteonecrosis of femoral head

The pathogenesis of steroid‐induced osteonecrosis of the femoral head (SONFH) involves a glucocorticoid‐induced imbalance of osteogenic and adipogenic differentiation, and apoptosis of bone marrow mesenchymal stem cells (BMSCs). An increasing number of genes, especially noncoding RNAs, have been imp...