Ovarian cancer ascites induces skeletal muscle wasting in vitro and reflects sarcopenia in patients

• Published in: Journal of cachexia, sarcopenia and muscle Vol. 13; no. 1; pp. 311 - 324
• Main Authors: Ubachs, Jorne, Worp, Wouter R.P.H., Vaes, Rianne D.W., Pasmans, Kenneth, Langen, Ramon C., Meex, Ruth C.R., Bijnen, Annemarie A.J.H.M., Lambrechts, Sandrina, Van Gorp, Toon, Kruitwagen, Roy F.P.M., Olde Damink, Steven W.M., Rensen, Sander S.
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.02.2022; John Wiley and Sons Inc; Wiley
• Subjects: Abdomen; Ascites; Ascites - etiology; Ascites - metabolism; Ascites - pathology; Atrogenes; Body composition; Body fat; C2C12 cells; Cachexia - diagnosis; Cancer therapies; Humans; Interleukin‐6; Metabolism; Muscle, Skeletal - pathology; Musculoskeletal system; Myotubes; NF‐κB; Original; Original : Clinical; Ovarian cancer; Ovarian Neoplasms - pathology; Patients; Protein breakdown; Protein synthesis; Proteins; Sarcopenia; Sarcopenia - diagnosis; Sarcopenia - etiology; Sarcopenia - metabolism; Tomography; Translational research; Values; Protein breakdown; NF-κB; Translational research; Myotubes; Protein synthesis; C2C12 cells; Atrogenes; Interleukin-6

Background Cachexia‐associated skeletal muscle wasting or ‘sarcopenia’ is highly prevalent in ovarian cancer and contributes to poor outcome. Drivers of cachexia‐associated sarcopenia in ovarian cancer remain elusive, underscoring the need for novel and better models to identify tumour factors induc...