Development and maintenance of the brain's immune toolkit: Microglia and non‐parenchymal brain macrophages

• Published in: Developmental neurobiology (Hoboken, N.J.) Vol. 78; no. 6; pp. 561 - 579
• Main Authors: Lopez‐Atalaya, Jose P., Askew, Katharine E., Sierra, Amanda, Gomez‐Nicola, Diego
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2018; John Wiley and Sons Inc
• Subjects: Animals; Brain; Brain - growth & development; Brain - immunology; Cell fate; Choroid plexus; development; Embryogenesis; Embryonic growth stage; External stimuli; Fate maps; Gene mapping; Homeostasis; Humans; Life span; lineage; Macrophages; Macrophages - immunology; Meninges; Microglia; Microglia - immunology; progenitor; Progenitor cells; Residential density; Review; self‐renewal; Stem cells; Transcription factors; Yolk; Yolk sac; lineage; progenitor; development; microglia; self-renewal

ABSTRACT Microglia and non‐parenchymal macrophages located in the perivascular space, the meninges and the choroid plexus are independent immune populations that play vital roles in brain development, homeostasis, and tissue healing. Resident macrophages account for a significant proportion of cells...