Chronic kidney disease and vitamin D metabolism in human bone marrow–derived MSCs

• Published in: Annals of the New York Academy of Sciences Vol. 1402; no. 1; pp. 43 - 55
• Main Authors: Zhou, Shuanhu, Glowacki, Julie
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2017
• Subjects: 1α,25(OH)2D; 25(OH)D; Age Factors; Autocrine signalling; Biocompatibility; Biomedical materials; Biosynthesis; bone; Bone marrow; Bone Marrow Cells - pathology; Bone mass; Calcium; CKD; CYP27B1; Cytochrome P450; Differentiation; Fibroblast growth factor 23; Growth factors; Humans; Hydroxylase; Insulin; Kidney - metabolism; Kidney - pathology; Kidney - physiopathology; Kidney diseases; Kidney transplantation; Kidneys; Liver; Mesenchymal Stromal Cells - metabolism; Mesenchymal Stromal Cells - pathology; Mesenchyme; Metabolic activation; Metabolic rate; Metabolism; MSCs; Osteoblastogenesis; Osteoblasts; Osteoblasts - metabolism; Paracrine signalling; Renal Insufficiency, Chronic - metabolism; Skin; Stem cells; Stromal cells; Synthesis; Vitamin D; Vitamin D - metabolism; vitamin D metabolism; CYP27B1; MSCs; 25(OH)D; bone; 1α,25(OH)2D; CKD

Vitamin D that is synthesized in the skin or is ingested undergoes sequential steps of metabolic activation via a cascade of cytochrome P450 enzymatic hydroxylations in the liver and kidney to produce 1α,25‐dihydroxyvitamin D (1α,25(OH)2D). There are many tissues that are able to synthesize 1α,25(OH...