Application of longitudinal item response theory models to modeling Parkinson’s disease progression

• Published in: CPT: pharmacometrics and systems pharmacology Vol. 11; no. 10; pp. 1382 - 1392
• Main Authors: Zou, Haotian, Aggarwal, Varun, Stebbins, Glenn T., Müller, Martijn L. T. M., Cedarbaum, Jesse M., Pedata, Anne, Stephenson, Diane, Simuni, Tanya, Luo, Sheng
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.10.2022; John Wiley and Sons Inc; Wiley
• Subjects: Clinical trials; Datasets; Disease Progression; Humans; Item response theory; Mental Status and Dementia Tests; Movement disorders; Observational studies; Parameter estimation; Parkinson Disease; Parkinson's disease; Patients; Severity of Illness Index

The Movement Disorder Society revised version of the Unified Parkinson’s Disease Rating Scale (MDS‐UPDRS) parts 2 and 3 reflect patient‐reported functional impact and clinician‐reported severity of motor signs of Parkinson’s disease (PD), respectively. Total scores are common clinical outcomes but m...