Calcium Channel Alterations in Genetic Hypertension

We proposed earlier that voltage-dependent calcium (Ca) current is altered in single azygos venous cells from Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). In this study, the effects of different intracellular concentrations of ethylene glycol-bis- N,N,Nʼ,NʼVtetraacetic acid (EG...

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Published inHypertension (Dallas, Tex. 1979) Vol. 14; no. 4; pp. 453 - 456
Main Authors Hermsmeyer, Kent, Rusch, Nancy J
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Heart Association, Inc 01.10.1989
Hagerstown, MD Lippincott
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Abstract We proposed earlier that voltage-dependent calcium (Ca) current is altered in single azygos venous cells from Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). In this study, the effects of different intracellular concentrations of ethylene glycol-bis- N,N,Nʼ,NʼVtetraacetic acid (EGTA) on Ca currents were investigated. Vascular muscle cells from SHR and WKY rats were equilibrated with pipette solution containing 0.1 mM or 10 mM EGTA. Increasing the EGTA concentration from 0.1 to 10 mM in SHR vascular cells significantly enhanced the peak amplitude of the longer lasting (L) current from 87 ±12 pA to 152 ±8 pA, while the transient (T) current amplitude was not significantly different (52 ±7 pA and 36±7 pA, respectively). In WKY rat vascular muscle cells, the amplitudes of the T and L currents were not significantly different with the same comparison of intracellular EGTA concentrations. These observations suggest that relatively low intracellular Ca concentrations can more strongly modulate Ca current through the L channel in SHR than WKY rat vascular muscle cells.
AbstractList We proposed earlier that voltage-dependent calcium (Ca2+) current is altered in single azygos venous cells from Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). In this study, the effects of different intracellular concentrations of ethylene glycol-bis-N,N,N',N',-tetraacetic acid (EGTA) on Ca2+ currents were investigated. Vascular muscle cells from SHR and WKY rats were equilibrated with pipette solution containing 0.1 mM or 10 mM EGTA. Increasing the EGTA concentration from 0.1 to 10 mM in SHR vascular cells significantly enhanced the peak amplitude of the longer lasting (L) current from 87 +/- 12 pA to 152 +/- 8 pA, while the transient (T) current amplitude was not significantly different (52 +/- 7 pA and 36 +/- 7 pA, respectively). In WKY rat vascular muscle cells, the amplitudes of the T and L currents were not significantly different with the same comparison of intracellular EGTA concentrations. These observations suggest that relatively low intracellular Ca2+ concentrations can more strongly modulate Ca2+ current through the L channel in SHR than WKY rat vascular muscle cells.
We proposed earlier that voltage-dependent calcium (Ca) current is altered in single azygos venous cells from Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). In this study, the effects of different intracellular concentrations of ethylene glycol-bis- N,N,Nʼ,NʼVtetraacetic acid (EGTA) on Ca currents were investigated. Vascular muscle cells from SHR and WKY rats were equilibrated with pipette solution containing 0.1 mM or 10 mM EGTA. Increasing the EGTA concentration from 0.1 to 10 mM in SHR vascular cells significantly enhanced the peak amplitude of the longer lasting (L) current from 87 ±12 pA to 152 ±8 pA, while the transient (T) current amplitude was not significantly different (52 ±7 pA and 36±7 pA, respectively). In WKY rat vascular muscle cells, the amplitudes of the T and L currents were not significantly different with the same comparison of intracellular EGTA concentrations. These observations suggest that relatively low intracellular Ca concentrations can more strongly modulate Ca current through the L channel in SHR than WKY rat vascular muscle cells.
Author Rusch, Nancy J
Hermsmeyer, Kent
AuthorAffiliation Cardiovascular Research Laboratory, Chiles Research Institute, Providence Medical Center and the Departments of Medicine and Cell Biology, Oregon Health Sciences University, Portland, Oregon and the Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin
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Issue 4
Keywords Hypertension
Cell culture
Calcium
Rat
Rodentia
Ion transport
Cardiovascular disease
Smooth muscle
Ionic channel
Hereditary
Vertebrata
Mammalia
Membrane transport
Animal
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Snippet We proposed earlier that voltage-dependent calcium (Ca) current is altered in single azygos venous cells from Wistar-Kyoto (WKY) rats and spontaneously...
We proposed earlier that voltage-dependent calcium (Ca2+) current is altered in single azygos venous cells from Wistar-Kyoto (WKY) rats and spontaneously...
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SubjectTerms Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Calcium - physiology
Calcium Channels - physiology
Cardiology. Vascular system
Cells, Cultured
Egtazic Acid - pharmacology
Experimental diseases
Hypertension - genetics
Hypertension - physiopathology
In Vitro Techniques
Medical sciences
Muscle, Smooth, Vascular - physiopathology
Rats
Rats, Inbred SHR - physiology
Rats, Inbred Strains - physiology
Rats, Inbred WKY
Title Calcium Channel Alterations in Genetic Hypertension
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