MCU Up‐regulation contributes to myocardial ischemia‐reperfusion Injury through calpain/OPA‐1–mediated mitochondrial fusion/mitophagy Inhibition - Guan, Lichun; Che, Zhimei; Meng, Xiangdong; Yu, Yong; Li, Minghui; Yu, Ziqin; Shi, Hui; Yang, Dicheng; Yu, Min (Journal of cellular and molecular medicine, 2019)
Keywords: Adenosine Triphosphate - biosynthesis; Animal models; Animals; Animals, Newborn; Apoptosis; Apoptosis - drug effects; Atrophy; Autophagy; Calcium (mitochondrial); Calcium Channels - genetics; Calcium Channels - metabolism; Calcium-Binding Proteins - metabolism; Calpain; Calpain - metabolism; Calpastatin; Cardiomyocytes; Cell culture; Cell injury; Enzyme Inhibitors - pharmacology; GTP Phosphohydrolases - metabolism; Heart; Homeostasis - drug effects; Hypoxia; Ischemia; ischemia/reperfusion (I/R); Laboratory animals; Male; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Mitochondria, Heart - drug effects; Mitochondria, Heart - metabolism; Mitochondria, Heart - ultrastructure; mitochondrial calcium uniporter (MCU); Mitochondrial Dynamics - drug effects; mitochondrial fission; Mitophagy; Mitophagy - drug effects; Morphology; Myocardial infarction; Myocardial Infarction - genetics; Myocardial Infarction - pathology; Myocardial ischemia; Myocardial Reperfusion Injury - genetics; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - pathology; Optic atrophy; Original; Protective Agents - pharmacology; Proteins; Rats; Reperfusion; Spermine; Transfection; Transgenic mice; Up-regulation; Up-Regulation - drug effects; China; calpain; mitophagy; ischemia/reperfusion (I/R); mitochondrial calcium uniporter (MCU); mitochondrial fission