Epigallocatechin gallate inhibits urate crystals-induced peritoneal inflammation in C57BL/6 mice

• Published in: Molecular nutrition & food research Vol. 60; no. 10; pp. 2297 - 2303
• Main Authors: Jhang, Jhih-Jia, Lu, Chi-Cheng, Yen, Gow-Chin
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.10.2016
• Subjects: amyloid; Animals; anti-inflammatory activity; antioxidant activity; blood serum; Catechin - analogs & derivatives; Catechin - pharmacology; Cell Line; chemokine CCL2; Chemokine CCL2 - metabolism; EGCG ⋅ IL-1β ⋅ Inflammation ⋅ MSU ⋅ NLRP3; epigallocatechin gallate; gout; green tea; Humans; inflammasomes; inflammation; interleukin-1beta; Interleukin-1beta - secretion; interleukin-6; Interleukin-6 - metabolism; intraperitoneal injection; Male; mice; Mice, Inbred C57BL; monocytes; Monocytes - drug effects; Monocytes - metabolism; Neutrophil Infiltration - drug effects; neutrophils; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; oligomerization; osteoarthritis; Peritonitis - chemically induced; Peritonitis - drug therapy; Peritonitis - metabolism; polyphenols; protein synthesis; rheumatoid arthritis; secretion; subcutaneous injection; Uric Acid - adverse effects; EGCG ⋅ IL-1β ⋅ Inflammation ⋅ MSU ⋅ NLRP3

Gouty arthritis is a type of monosodium urate (MSU) crystals‐induced inflammation in the articular tissue and shows the increased levels of neutrophil infiltration and IL‐1β secretion. MSU is capable of activating IL‐1β through a nucleotide‐binding oligomerization domain‐like receptor containing pyr...