Alteration of select gene expression patterns in individuals infected with HIV-1

• Published in: Journal of medical virology Vol. 86; no. 4; pp. 678 - 686
• Main Authors: Serrao, Erik, Wang, Chia-Hao, Frederick, Toinette, Lee, Chi-Lin, Anthony, Patricia, Arribas-Layton, David, Baker, Kerry, Millstein, Joshua, Kovacs, Andrea, Neamati, Nouri
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.04.2014; Wiley Subscription Services, Inc
• Subjects: Adaptor Proteins, Signal Transducing - biosynthesis; Adaptor Proteins, Signal Transducing - genetics; Adolescent; Adult; Antiretroviral drugs; APOBEC-3G Deaminase; APOBEC3G; CD4-Positive T-Lymphocytes - immunology; Child; Cross-Sectional Studies; Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cytidine Deaminase - biosynthesis; Cytidine Deaminase - genetics; Female; Gene Expression; Gene Expression Regulation; HIV; HIV Infections - drug therapy; HIV Infections - immunology; HIV-1 - genetics; HSP90; HSP90 Heat-Shock Proteins - biosynthesis; HSP90 Heat-Shock Proteins - genetics; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Intercellular Signaling Peptides and Proteins - biosynthesis; Intercellular Signaling Peptides and Proteins - genetics; LEDGF/p75; Male; Middle Aged; p21/WAF1; Proteins; Pyrrolidinones - therapeutic use; Raltegravir Potassium; RNA, Messenger - biosynthesis; Transcription Factors - biosynthesis; Transcription Factors - genetics; Virology; Young Adult; HSP90; p21/WAF1; LEDGF/p75; APOBEC3G; HIV; gene expression

Multiple human proteins have been shown to both support and restrict viral replication, and confirmation of virus‐associated changes in the expression of these genes is relevant for future therapeutic efforts. In this study a well‐characterized panel of 49 individuals either infected with HIV‐1 or u...