Cdc42 functions as a regulatory node for tumour‐derived microvesicle biogenesis

• Published in: Journal of extracellular vesicles Vol. 10; no. 3; pp. e12051 - n/a
• Main Authors: Wang, Jing, Zhuang, Xiangjin, Greene, Kai Su, Si, Ha, Antonyak, Marc A., Druso, Joseph E., Wilson, Kristin F., Cerione, Richard A., Feng, Qiyu, Wang, Hongyang
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2021; John Wiley and Sons Inc; Wiley
• Subjects: 3T3 Cells; Angiogenesis; Animals; Biosynthesis; Brain cancer; Cancer therapies; Cdc42; cdc42 GTP-Binding Protein - metabolism; Cdc42 protein; Cell Communication; Cell interactions; Cell Line; Cell Line, Tumor; Cell surface; Cell surface receptors; Cell-Derived Microparticles - metabolism; Cells; EGF signalling; Epidermal growth factor; Extracellular vesicles; Extracellular Vesicles - metabolism; Fibroblasts; GTPase; Humans; Internalization; IQGAP; IQGAP1 protein; Kinases; Mice; Microscopy; Microvesicle; Molecular modelling; Neoplasms - metabolism; Neovascularization, Pathologic - metabolism; Proteins; ras GTPase-Activating Proteins - metabolism; Signal Transduction; Tumor Microenvironment; Tumorigenesis; tumour angiogenesis; Vascular endothelial growth factor; EGF signalling; IQGAP; tumour angiogenesis; GTPase; Microvesicle; Cdc42

Tumour‐derived microvesicles (MVs) serve as critical mediators of cell‐to‐cell communication in the tumour microenvironment. So far, the underlying mechanisms of MV biogenesis, especially how key tumorigenesis signals such as abnormal EGF signalling regulates MV release, remain unclear. Here, we set...