Obesity and the risk of Multiple Sclerosis. The role of Leptin

• Published in: Annals of clinical and translational neurology Vol. 8; no. 2; pp. 406 - 424
• Main Authors: Marrodan, Mariano, Farez, Mauricio F., Balbuena Aguirre, Maria E., Correale, Jorge
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.02.2021; John Wiley and Sons Inc; Wiley
• Subjects: Adolescent; Adult; Age; Antigens; Body mass index; Cell Proliferation; Child development; Cloning; Cross-Sectional Studies; Cytokines; Dietary supplements; Disease; Female; Females; Hormones; Humans; Leptin - blood; Leptin - metabolism; Lymphocytes; Male; MAP Kinase Signaling System; Middle Aged; Multiple sclerosis; Multiple Sclerosis - etiology; Obesity; Obesity - complications; Obesity - diagnosis; Overweight; Penicillin; Peptides; Receptors, Leptin - metabolism; Risk Factors; STAT3 Transcription Factor; T-Lymphocytes - metabolism; Young Adult

Objective To investigate the effects of leptin on different T‐cell populations, in order to gain more insight into the link between leptin and obesity. Methods Three hundred and nine RRMS patients and 322 controls participated in a cross‐sectional survey, to confirm whether excess weight/obesity in...