Longitudinal change in TSPO PET imaging in progressive multiple sclerosis

The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC withi...

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Published inAnnals of clinical and translational neurology Vol. 8; no. 8; pp. 1755 - 1759
Main Authors Kang, Yeona, Pandya, Sneha, Zinger, Nicole, Michaelson, Nara, Gauthier, Susan A.
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.08.2021
John Wiley and Sons Inc
Wiley
Subjects
Adult
Age
Automation
COVID-19
Female
Gray Matter - diagnostic imaging
Gray Matter - metabolism
Humans
Isoquinolines - pharmacokinetics
Longitudinal Studies
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis, Chronic Progressive - diagnostic imaging
Multiple Sclerosis, Chronic Progressive - metabolism
Pilot Projects
Positron-Emission Tomography
Radiopharmaceuticals - pharmacokinetics
Receptors, GABA - metabolism
Short Communication
White Matter - diagnostic imaging
White Matter - metabolism
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Abstract The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal‐appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM (p = 0.01), cortex (p = 0.04), thalamus (p = 0.04), and putamen (p = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195. Our data suggest that innate immune activity may increase over time in patients with progressive MS.
AbstractList Abstract The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal‐appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM (p = 0.01), cortex (p = 0.04), thalamus (p = 0.04), and putamen (p = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195. Our data suggest that innate immune activity may increase over time in patients with progressive MS.
The objective of this pilot study was to assess a 2-year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195-PET. Sixteen age-matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal-appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM (p = 0.01), cortex (p = 0.04), thalamus (p = 0.04), and putamen (p = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195. Our data suggest that innate immune activity may increase over time in patients with progressive MS.
The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal‐appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM ( p  = 0.01), cortex ( p  = 0.04), thalamus ( p  = 0.04), and putamen ( p  = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195. Our data suggest that innate immune activity may increase over time in patients with progressive MS.
The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal‐appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM (p = 0.01), cortex (p = 0.04), thalamus (p = 0.04), and putamen (p = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195. Our data suggest that innate immune activity may increase over time in patients with progressive MS.
Abstract The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195‐PET. Sixteen age‐matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal‐appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM ( p  = 0.01), cortex ( p  = 0.04), thalamus ( p  = 0.04), and putamen ( p  = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195. Our data suggest that innate immune activity may increase over time in patients with progressive MS.
Author Pandya, Sneha
Kang, Yeona
Zinger, Nicole
Gauthier, Susan A.
Michaelson, Nara
AuthorAffiliation 3 Department of Neurology Weill Cornell Medicine New York New York USA
2 Department of Radiology Weill Cornell Medicine New York New York USA
1 Department of Mathematics Howard University Washington District of Columbia USA
4 Feil Brain and Mind Institute Weill Cornell Medicine New York New York USA
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  surname: Pandya
  fullname: Pandya, Sneha
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  givenname: Nicole
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  fullname: Zinger, Nicole
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  fullname: Gauthier, Susan A.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34310086$$D View this record in MEDLINE/PubMed
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10.1038/jcbfm.2012.59
10.1093/brain/awh641
10.1172/JCI90609
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10.1111/j.1750-3639.2010.00466.x
10.1056/NEJM199801293380502
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10.1371/journal.pone.0201289
10.2967/jnumed.113.131698
ContentType Journal Article
Copyright 2021 The Authors. published by Wiley Periodicals LLC on behalf of American Neurological Association.
2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Snippet The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195‐PET....
The objective of this pilot study was to assess a 2-year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195-PET....
Abstract The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using...
Abstract The objective of this pilot study was to assess a 2‐year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using...
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Age
Automation
COVID-19
Female
Gray Matter - diagnostic imaging
Gray Matter - metabolism
Humans
Isoquinolines - pharmacokinetics
Longitudinal Studies
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis, Chronic Progressive - diagnostic imaging
Multiple Sclerosis, Chronic Progressive - metabolism
Pilot Projects
Positron-Emission Tomography
Radiopharmaceuticals - pharmacokinetics
Receptors, GABA - metabolism
Short Communication
White Matter - diagnostic imaging
White Matter - metabolism
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Title Longitudinal change in TSPO PET imaging in progressive multiple sclerosis
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Facn3.51431
https://www.ncbi.nlm.nih.gov/pubmed/34310086
https://www.proquest.com/docview/2559397544
https://search.proquest.com/docview/2555346046
https://pubmed.ncbi.nlm.nih.gov/PMC8351399
https://doaj.org/article/f6d5c88a07614bbea10c13a0ed3a23be
Volume 8
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