Advanced Maternal Age‐associated SIRT1 Deficiency Compromises Trophoblast Epithelial−Mesenchymal Transition through an Increase in Vimentin Acetylation

• Published in: Aging cell Vol. 20; no. 10; pp. e13491 - n/a
• Main Authors: Xiong, Liling, Ye, Xuan, Chen, Zhi, Fu, Huijia, Li, Sisi, Xu, Ping, Yu, Jiaxiao, Wen, Li, Gao, Rufei, Fu, Yong, Qi, Hongbo, Kilby, Mark D., Saffery, Richard, Baker, Philip N., Tong, Chao
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.10.2021; John Wiley and Sons Inc
• Subjects: Acetylation; Achievement tests; advanced maternal age; Age; Aged; Animals; Biomarkers; Cell cycle; Cross-breeding; Embryos; Epithelial-Mesenchymal Transition - immunology; epithelial−mesenchymal transition; Female; Fetuses; Humans; Invasiveness; Life cycles; Mass spectroscopy; Maternal Age; Mesenchyme; Mice; NAD; Original Paper; Original Papers; p53 Protein; Placenta; Pregnancy; Protein expression; Proteins; Senescence; SIRT1; SIRT1 protein; Sirtuin 1 - metabolism; Therapeutic targets; trophoblast; Trophoblasts; Trophoblasts - metabolism; Vimentin; Vimentin - adverse effects; Wound healing; senescence; epithelial−mesenchymal transition; placenta; trophoblast; SIRT1; advanced maternal age

Advanced maternal age (AMA) pregnancies are rapidly increasing and are associated with aberrant trophoblast cell function, poor placentation, and unfavorable pregnancy outcomes, presumably due to premature placental senescence. SIRT1 is an NAD+‐dependent deacetylase with well‐known antiaging effects...