Comparative oncology: The paradigmatic example of canine and human mast cell neoplasms

• Published in: Veterinary & comparative oncology Vol. 17; no. 1; pp. 1 - 10
• Main Authors: Willmann, Michael, Hadzijusufovic, Emir, Hermine, Olivier, Dacasto, Mauro, Marconato, Laura, Bauer, Karin, Peter, Barbara, Gamperl, Susanne, Eisenwort, Gregor, Jensen‐Jarolim, Erika, Müller, Mathias, Arock, Michel, Vail, David M., Valent, Peter
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2019
• Subjects: Animals; Antineoplastic Agents - therapeutic use; canine mast cell neoplasm; CD25; CD30; Dog Diseases - drug therapy; Dogs; enzyme inhibitors; evolution; Humans; KIT mutations; mast cells; Mastocytoma - classification; Mastocytoma - drug therapy; Mastocytoma - veterinary; mutation; prognosis; Review; skin neoplasms; Species Specificity; tryptase; CD30; canine mast cell neoplasm; CD25; KIT mutations; tryptase

In humans, advanced mast cell (MC) neoplasms are rare malignancies with a poor prognosis. Only a few preclinical models are available, and current treatment options are limited. In dogs, MC neoplasms are the most frequent malignant skin tumours. Unlike low‐grade MC neoplasms, high‐grade MC disorders...