Concentration‐QTc Modeling of Ozanimod’s Major Active Metabolites in Adult Healthy Subjects - Briggs, Emily; Chapel, Sunny; Zhang, Peijin; Palmisano, Maria; Tran, Jonathan Q. (CPT: pharmacometrics and systems pharmacology, 2021)
Keywords: Administration, Oral; Adult; Case-Control Studies; Double-Blind Method; Drug dosages; Electrocardiography; Electrocardiography - drug effects; Female; Healthy Volunteers; Heart Rate - drug effects; Humans; Indans - administration & dosage; Indans - adverse effects; Indans - pharmacokinetics; Long QT Syndrome; Male; Metabolites; Multiple Sclerosis, Relapsing-Remitting - drug therapy; Oxadiazoles - administration & dosage; Oxadiazoles - adverse effects; Oxadiazoles - pharmacokinetics; Pharmacokinetics; Placebos - administration & dosage; Predictive Value of Tests; Sphingosine 1 Phosphate Receptor Modulators - administration & dosage; Sphingosine 1 Phosphate Receptor Modulators - adverse effects; Sphingosine 1 Phosphate Receptor Modulators - pharmacokinetics; Sphingosine-1-Phosphate Receptors - metabolism; Values