CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development

• Published in: The Journal of neuroscience Vol. 34; no. 4; pp. 1370 - 1379
• Main Authors: Tanaka, Tomohiro, Wakabayashi, Tomoko, Oizumi, Hiroaki, Nishio, Shu, Sato, Takashi, Harada, Akihiro, Fujii, Daisuke, Matsuo, Yuko, Hashimoto, Tadafumi, Iwatsubo, Takeshi
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 22.01.2014
• Subjects: Animals; Collagen - metabolism; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Mice; Mice, Knockout; Motor Neurons - cytology; Motor Neurons - metabolism; Muscle, Skeletal - innervation; Neurogenesis - physiology; Neuromuscular Junction - growth & development; Neuromuscular Junction - metabolism; Reverse Transcriptase Polymerase Chain Reaction

Formation of proper neuromuscular connections is a process coordinated by both motoneuron-intrinsic and target-dependent programs. Under these programs, motoneurons innervate target muscles, escape programmed cell death during fetal development, and form neuromuscular junctions (NMJ). Although a num...