miR-153 enhances the therapeutic effect of radiotherapy by targeting JAG1 in pancreatic cancer cells

• Published in: Oncology letters Vol. 21; no. 4; p. 300
• Main Authors: Zhao, Zhibin, Shen, Xiaoxue, Zhang, Dongli, Xiao, Hongmei, Kong, Hongfang, Yang, Bin, Yang, Li
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.04.2021; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Antibodies; Apoptosis; Binding sites; Cancer; Cancer therapies; Care and treatment; Cell culture; Computer software industry; Flow cytometry; Health aspects; Laboratory animals; Lung cancer; Medical prognosis; MicroRNAs; Oncology; Pancreatic cancer; Proteins; Radiation therapy; Radiotherapy; RNA; Scientific equipment and supplies industry; Software; Statistical analysis; Survival analysis; United States; China; cell apoptosis; pancreatic cancer; microRNA-153; radioresistance; jagged canonical Notch ligand 1

Pancreatic cancer is one of the deadliest diseases, due to the lack of early symptoms and resistance to current therapies, including radiotherapy. However, the mechanisms of radioresistance in pancreatic cancer remain unknown. The present study explored the role of microRNA-153 (miR-153) in radiores...