Bladder Tumor Contains Higher N7-Methylguanine Levels in DNA than Adjacent Normal Bladder Epithelium

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 15; no. 4; pp. 740 - 743
• Main Authors: Saad, Abir A., O'Connor, Peter J., Mostafa, Mostafa H., Metwalli, Nabila E., Cooper, Donald P., Margison, Geoffrey P., Povey, Andrew C.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.04.2006
• Subjects: Bacterial Infections - complications; Biological and medical sciences; Bladder cancer; DNA Adducts - analysis; DNA Methylation; Egypt; Epithelium - chemistry; Female; Guanine - analogs & derivatives; Guanine - analysis; Humans; Male; Medical sciences; Middle Aged; N7-methylguanine; Nephrology. Urinary tract diseases; Nitrosamines; Schistosoma; Schistosomiasis; Schistosomiasis haematobia - complications; Tumors; Tumors of the urinary system; Urinary Bladder - chemistry; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - pathology; Urinary tract. Prostate gland; Human; Urinary system disease; Cancerology; DNA; Guanine derivatives; Genetics; Bladder disease; Malignant tumor; Urinary tract disease; Bladder cancer; Carcinogenesis; Molecular adduct

Schistosoma haematobium –infected patients are more likely to develop bladder cancer and be more exposed to carcinogenic N -nitroso compounds than uninfected patients. As N7-methylguanine is a marker of exposure to methylating agents of this type, we have measured N7-methyldeoxyguanosine 3′-monophos...