Cellular immunology of relapsing multiple sclerosis: interactions, checks, and balances

• Published in: Lancet neurology Vol. 20; no. 6; pp. 470 - 483
• Main Authors: Bar-Or, Amit, Li, Rui
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2021; Elsevier Limited
• Subjects: Antigens; Autoimmune diseases; B-Lymphocytes - immunology; Brain; Chemokines; Clinical trials; Cytokines; Disease Progression; Effector cells; Functional plasticity; Glycoproteins; Humans; Immunology; Immunopathogenesis; Immunotherapy - trends; Inflammation; Lymphocytes; Lymphocytes B; Lymphocytes T; Multiple sclerosis; Multiple Sclerosis - drug therapy; Multiple Sclerosis - immunology; Multiple Sclerosis - physiopathology; Multiple Sclerosis, Relapsing-Remitting - drug therapy; Multiple Sclerosis, Relapsing-Remitting - immunology; Multiple Sclerosis, Relapsing-Remitting - physiopathology; Myeloid cells; Myeloid Cells - immunology; Pathogenesis; Recurrence; T-Lymphocytes - immunology; Tumor necrosis factor-TNF

Novel insights from basic and translational studies are reshaping concepts of the immunopathogenesis of multiple sclerosis and understanding of the different inflammatory responses throughout the disease course. Previously, the cellular immunology of relapsing multiple sclerosis was considered to be...