Genistein reduced insulin resistance index through modulating lipid metabolism in ovariectomized rats

• Published in: Nutrition research (New York, N.Y.) Vol. 32; no. 11; pp. 844 - 855
• Main Authors: Choi, Joo Sun, Koh, In-Uk, Song, Jihyun
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.11.2012; Elsevier
• Subjects: Adipose Tissue - cytology; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Animals; Biological and medical sciences; Carnitine O-Palmitoyltransferase - metabolism; Diet, High-Fat - adverse effects; Dietary genistein; Dietary Supplements; Disease Models, Animal; Fatty Acid Synthases - metabolism; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology and Hepatology; Gene Expression - drug effects; Genistein - pharmacology; Genistein - therapeutic use; Glycine max - chemistry; Insulin resistance; Insulin Resistance - genetics; Lipid Metabolism - drug effects; Lipid Metabolism - genetics; Liver - drug effects; Liver - enzymology; Microarray; Microarray Analysis; Mitochondrial function; Obesity - etiology; Obesity - genetics; Obesity - metabolism; Ovariectomy; Oxidation-Reduction; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - genetics; Phytoestrogens - pharmacology; Phytoestrogens - therapeutic use; Phytotherapy; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Postmenopause; Rat; Rats; Rats, Sprague-Dawley; Succinate Dehydrogenase - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Weight Gain; β-Oxidation; Oxidative stress; Chol; Rat; Gene Map Annotator and Pathway Profiler; CPT; Sham; fatty acid synthetase; 2,6-dichloroindolphenol; cytochrome c oxidase; Dietary genistein; sham surgery; Microarray; OVX; complementary DNA; gene ontology; carnitine palmitoyltransferase; Mitochondrial function; SDH; cholesterol; KEGG; TNF α; cDNA; gene-set enrichment analysis; GenMAPP; Ovariectomy; β-Oxidation; GO; Kyoto Encyclopedia of Genes and Genomes; GSEA; IR; significance analysis of microarrays; COX; ER; estrogen receptors; succinate dehydrogenase; tumor necrosis factor- α; Insulin resistance; DCIP; FAS; SAM; TNFα; Endocrinopathy; Isoflavone; Genistein; Rodentia; Metabolic diseases; Lipids; Index; Metabolism; Target tissue resistance; Vertebrata; Mitochondria; Mammalia; β Oxidation; Animal

Abstract Postmenopausal women are at higher risk for obesity and insulin resistance due to the decline of estrogen, but genistein, a phytoestrogen, may reduce the risks of these diet-related diseases. In this study, we hypothesized that supplemental genistein has beneficial effects on insulin resist...