Genistein reduced insulin resistance index through modulating lipid metabolism in ovariectomized rats

Abstract Postmenopausal women are at higher risk for obesity and insulin resistance due to the decline of estrogen, but genistein, a phytoestrogen, may reduce the risks of these diet-related diseases. In this study, we hypothesized that supplemental genistein has beneficial effects on insulin resist...

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Published inNutrition research (New York, N.Y.) Vol. 32; no. 11; pp. 844 - 855
Main Authors Choi, Joo Sun, Koh, In-Uk, Song, Jihyun
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.11.2012
Elsevier
Subjects
Rat
Rat
CPT
OVX
SDH
GO
IR
COX
ER
FAS
SAM
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Abstract Abstract Postmenopausal women are at higher risk for obesity and insulin resistance due to the decline of estrogen, but genistein, a phytoestrogen, may reduce the risks of these diet-related diseases. In this study, we hypothesized that supplemental genistein has beneficial effects on insulin resistance in an ovariectomized rat model by modulating lipid metabolism. Three weeks after a sham surgery (sham) or an ovariectomy (OVX), ovariectomized Sprague-Dawley rats were placed on a diet containing 0 (OVX group) or 0.1% genistein for 4 weeks. The sham rats were fed a high-fat diet containing 0% genistein and served as the control group (sham group). The ovariectomized rats showed increases in body weight and insulin resistance index, but genistein reduced insulin resistance index and the activity of hepatic fatty acid synthetase. Genistein was also associated with increased activity of succinate dehydrogenase and carnitine palmitoyltransferase and the rate of β -oxidation in the fat tissue of rats. The ovariectomized rats given genistein had smaller-sized adipocytes. Using gene-set enrichment analysis (GSEA) of microarray data, we found that a number of gene sets of fatty acid metabolism, insulin resistance, and oxidative stress were differentially expressed by OVX and reversed by genistein. This systemic approach of GSEA enables the identification of such consensus between the gene expression changes and phenotypic changes caused by OVX and genistein supplementation. Genistein treatment could help reduce insulin resistance through the amelioration of OVX-induced metabolic dysfunction, and the GSEA approach may be useful in proposing putative targets related to insulin resistance.
AbstractList Postmenopausal women are at higher risk for obesity and insulin resistance due to the decline of estrogen, but genistein, a phytoestrogen, may reduce the risks of these diet-related diseases. In this study, we hypothesized that supplemental genistein has beneficial effects on insulin resistance in an ovariectomized rat model by modulating lipid metabolism. Three weeks after a sham surgery (sham) or an ovariectomy (OVX), ovariectomized Sprague-Dawley rats were placed on a diet containing 0 (OVX group) or 0.1% genistein for 4 weeks. The sham rats were fed a high-fat diet containing 0% genistein and served as the control group (sham group). The ovariectomized rats showed increases in body weight and insulin resistance index, but genistein reduced insulin resistance index and the activity of hepatic fatty acid synthetase. Genistein was also associated with increased activity of succinate dehydrogenase and carnitine palmitoyltransferase and the rate of β-oxidation in the fat tissue of rats. The ovariectomized rats given genistein had smaller-sized adipocytes. Using gene-set enrichment analysis (GSEA) of microarray data, we found that a number of gene sets of fatty acid metabolism, insulin resistance, and oxidative stress were differentially expressed by OVX and reversed by genistein. This systemic approach of GSEA enables the identification of such consensus between the gene expression changes and phenotypic changes caused by OVX and genistein supplementation. Genistein treatment could help reduce insulin resistance through the amelioration of OVX-induced metabolic dysfunction, and the GSEA approach may be useful in proposing putative targets related to insulin resistance.
Abstract Postmenopausal women are at higher risk for obesity and insulin resistance due to the decline of estrogen, but genistein, a phytoestrogen, may reduce the risks of these diet-related diseases. In this study, we hypothesized that supplemental genistein has beneficial effects on insulin resistance in an ovariectomized rat model by modulating lipid metabolism. Three weeks after a sham surgery (sham) or an ovariectomy (OVX), ovariectomized Sprague-Dawley rats were placed on a diet containing 0 (OVX group) or 0.1% genistein for 4 weeks. The sham rats were fed a high-fat diet containing 0% genistein and served as the control group (sham group). The ovariectomized rats showed increases in body weight and insulin resistance index, but genistein reduced insulin resistance index and the activity of hepatic fatty acid synthetase. Genistein was also associated with increased activity of succinate dehydrogenase and carnitine palmitoyltransferase and the rate of β -oxidation in the fat tissue of rats. The ovariectomized rats given genistein had smaller-sized adipocytes. Using gene-set enrichment analysis (GSEA) of microarray data, we found that a number of gene sets of fatty acid metabolism, insulin resistance, and oxidative stress were differentially expressed by OVX and reversed by genistein. This systemic approach of GSEA enables the identification of such consensus between the gene expression changes and phenotypic changes caused by OVX and genistein supplementation. Genistein treatment could help reduce insulin resistance through the amelioration of OVX-induced metabolic dysfunction, and the GSEA approach may be useful in proposing putative targets related to insulin resistance.
Author Song, Jihyun
Choi, Joo Sun
Koh, In-Uk
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Cites_doi 10.1016/S0021-9258(18)45614-1
10.1210/endo.138.3.4984
10.1016/S0092-8674(00)00015-5
10.1007/BF00280883
10.1111/j.1463-1326.2005.00545.x
10.2337/db07-0630
10.1016/j.tibtech.2005.05.011
10.1038/sj.ijo.0802054
10.1152/ajpendo.2001.281.4.E803
10.1093/bioinformatics/btg455
10.1126/science.278.5338.680
10.1016/j.nut.2005.12.014
10.1016/S0378-5122(99)00073-0
10.1210/en.2003-0076
10.1016/j.metabol.2008.08.004
10.1016/0003-2697(72)90061-9
10.1186/1471-2105-6-144
10.1042/bj1200237
10.1093/jn/131.10.3018
10.1093/jn/136.2.409
10.1530/eje.0.1420307
10.1016/S0026-0495(03)00181-1
10.1016/0003-9861(81)90320-9
10.1016/j.mce.2004.03.011
10.1093/bioinformatics/bth088
10.1186/1477-7827-3-6
10.1038/oby.2003.65
10.1038/ng0502-19
10.1002/mnfr.200900127
10.1210/endo.138.3.4979
10.1016/j.phytochem.2004.03.005
10.1097/00042192-200007040-00004
ContentType Journal Article
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Issue 11
Keywords Oxidative stress
Chol
Rat
Gene Map Annotator and Pathway Profiler
CPT
Sham
fatty acid synthetase
2,6-dichloroindolphenol
cytochrome c oxidase
Dietary genistein
sham surgery
Microarray
OVX
complementary DNA
gene ontology
carnitine palmitoyltransferase
Mitochondrial function
SDH
cholesterol
KEGG
TNF α
cDNA
gene-set enrichment analysis
GenMAPP
Ovariectomy
β-Oxidation
GO
Kyoto Encyclopedia of Genes and Genomes
GSEA
IR
significance analysis of microarrays
COX
ER
estrogen receptors
succinate dehydrogenase
tumor necrosis factor- α
Insulin resistance
DCIP
FAS
SAM
TNFα
Endocrinopathy
Isoflavone
Genistein
Rodentia
Metabolic diseases
Lipids
Index
Metabolism
Target tissue resistance
Vertebrata
Mitochondria
Mammalia
β Oxidation
Animal
Language English
License CC BY 4.0
Copyright © 2012 Elsevier Inc. All rights reserved.
https://www.elsevier.com/tdm/userlicense/1.0
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PublicationTitle Nutrition research (New York, N.Y.)
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References Shadoan, Anthony, Rankin, Clarkson, Wagner (bb0025) 2003; 52
Pan, Anthony, Watson, Clarkson (bb0065) 2000; 7
Kim, Volsky (bb0140) 2005; 8
Liang, Akishita, Kim, Ako, Hashimoto, Ljima (bb0010) 2002; 26
Murase, Nagasawa, Suzuki, Wakisaka, Hase, Tokimitsu (bb0120) 2002; 132
Saengsirisuwan, Pongdeesa, Prasannarong, Vichaiwong, Toskulkao (bb0015) 2009; 58
Mohamed, Abdel-rahman (bb0150) 2000; 142
Choi, Kim, Jung, Hong, Song (bb0100) 2010; 54
Kim, Shin, Kim, Kim, Lee, Kim (bb0060) 2004; 220
Lee, Choi, Kim, Jung, Lee, Song (bb0070) 2006; 22
Bieber, Abraham, Helmrath (bb0125) 1972; 50
Kim, Nelson-Dooley, Della-Fera, Yang, Zhang, Duan (bb0165) 2006; 136
Al-Shahrour, Az-Uriarte, Dopazo (bb0095) 2004; 20
Linn (bb0130) 1981; 209
Hughes, Marton, Jones, Roberts, Stoughton, Armour (bb0080) 2000; 102
Wharton, Tzogaloff (bb0115) 1967; Vol 10
Dahlquist, Salomonis, Vranizan, Lawlor, Conklin (bb0135) 2002; 31
Zhao, Tian, Hao, Chen (bb0145) 2005; 3
Matthews, Hosker, Rudenski (bb0105) 1985; 28
DeRisi, Lyer, Brown (bb0075) 1997; 278
Darimont, Delansorne, Paris, Ailhaud, Negrel (bb0155) 1997; 138
van Seumeren (bb0005) 2000; 34
Curtis, Oresic, Vidal-Puig (bb0085) 2005; 23
Cornwell, Cohick, Raskin (bb0050) 2004; 65
Lemieux, Picard, Labrie, Richard, Deshaies (bb0020) 2003; 11
Cederroth, Vinciguerra, Gjinovci, Kühne, Klein, Cederroth (bb0055) 2008; 57
Beissbarth, Speed (bb0090) 2004; 20
Akiyama, Ishida, Nakagawa, Ogawara, Watanabe, Itoh (bb0045) 1987; 262
Campbell, Febbraio (bb0035) 2001; 281
Naaz, Yellayi, Zakroczymski, Bunick, Doerge, Lubahn (bb0160) 2003; 144
Salpeter, Walsh, Ormiston, Greyber, Buckley, Salpeter (bb0030) 2006; 8
Kuiper, Carlsson, Grandien, Enmark, Häggblad, Nilsson (bb0040) 1997; 138
Owen, Freer (bb0110) 1970; 120
Campbell (10.1016/j.nutres.2012.10.002_bb0035) 2001; 281
Kim (10.1016/j.nutres.2012.10.002_bb0140) 2005; 8
Naaz (10.1016/j.nutres.2012.10.002_bb0160) 2003; 144
Linn (10.1016/j.nutres.2012.10.002_bb0130) 1981; 209
Matthews (10.1016/j.nutres.2012.10.002_bb0105) 1985; 28
Hughes (10.1016/j.nutres.2012.10.002_bb0080) 2000; 102
Murase (10.1016/j.nutres.2012.10.002_bb0120) 2002; 132
Kim (10.1016/j.nutres.2012.10.002_bb0060) 2004; 220
Al-Shahrour (10.1016/j.nutres.2012.10.002_bb0095) 2004; 20
Lee (10.1016/j.nutres.2012.10.002_bb0070) 2006; 22
Beissbarth (10.1016/j.nutres.2012.10.002_bb0090) 2004; 20
Pan (10.1016/j.nutres.2012.10.002_bb0065) 2000; 7
Saengsirisuwan (10.1016/j.nutres.2012.10.002_bb0015) 2009; 58
Cederroth (10.1016/j.nutres.2012.10.002_bb0055) 2008; 57
Curtis (10.1016/j.nutres.2012.10.002_bb0085) 2005; 23
Kuiper (10.1016/j.nutres.2012.10.002_bb0040) 1997; 138
Lemieux (10.1016/j.nutres.2012.10.002_bb0020) 2003; 11
Salpeter (10.1016/j.nutres.2012.10.002_bb0030) 2006; 8
Akiyama (10.1016/j.nutres.2012.10.002_bb0045) 1987; 262
Wharton (10.1016/j.nutres.2012.10.002_bb0115) 1967; Vol 10
Bieber (10.1016/j.nutres.2012.10.002_bb0125) 1972; 50
Owen (10.1016/j.nutres.2012.10.002_bb0110) 1970; 120
Mohamed (10.1016/j.nutres.2012.10.002_bb0150) 2000; 142
DeRisi (10.1016/j.nutres.2012.10.002_bb0075) 1997; 278
Liang (10.1016/j.nutres.2012.10.002_bb0010) 2002; 26
Dahlquist (10.1016/j.nutres.2012.10.002_bb0135) 2002; 31
Kim (10.1016/j.nutres.2012.10.002_bb0165) 2006; 136
van Seumeren (10.1016/j.nutres.2012.10.002_bb0005) 2000; 34
Darimont (10.1016/j.nutres.2012.10.002_bb0155) 1997; 138
Cornwell (10.1016/j.nutres.2012.10.002_bb0050) 2004; 65
Shadoan (10.1016/j.nutres.2012.10.002_bb0025) 2003; 52
Choi (10.1016/j.nutres.2012.10.002_bb0100) 2010; 54
Zhao (10.1016/j.nutres.2012.10.002_bb0145) 2005; 3
References_xml – volume: 138
  start-page: 863
  year: 1997
  end-page: 870
  ident: bb0040
  article-title: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
  publication-title: Endocrinol
  contributor:
    fullname: Nilsson
– volume: 65
  start-page: 995
  year: 2004
  end-page: 1016
  ident: bb0050
  article-title: Dietary phytoestrogens and health
  publication-title: Phytochem
  contributor:
    fullname: Raskin
– volume: 57
  start-page: 1176
  year: 2008
  end-page: 1185
  ident: bb0055
  article-title: Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism
  publication-title: Diabetes
  contributor:
    fullname: Cederroth
– volume: 50
  start-page: 509
  year: 1972
  end-page: 518
  ident: bb0125
  article-title: A rapid spectrophotometric assay for carnitine palmitoyltransferase
  publication-title: Anal Biochem
  contributor:
    fullname: Helmrath
– volume: 132
  start-page: 3018
  year: 2002
  end-page: 3022
  ident: bb0120
  article-title: Dietary alpha-linolenic acid–rich diacylglycerols reduce body weight gain accompanying the stimulation of intestinal beta-oxidation and related gene expressions in C57BL/KsJ-db/db mice
  publication-title: J Nutr
  contributor:
    fullname: Tokimitsu
– volume: 3
  start-page: 6
  year: 2005
  ident: bb0145
  article-title: Extragonadal aromatization increases with time after ovariectomy in rats
  publication-title: Reprod Biol Endocrinol
  contributor:
    fullname: Chen
– volume: 278
  start-page: 680
  year: 1997
  end-page: 686
  ident: bb0075
  article-title: Exploring the metabolic and genetic control of gene expression on a genomic scale
  publication-title: Science
  contributor:
    fullname: Brown
– volume: 281
  start-page: E803
  year: 2001
  end-page: E808
  ident: bb0035
  article-title: Effect of ovarian hormones on mitochondrial enzyme activity in the fat oxidation pathway of skeletal muscle
  publication-title: Am J Physiol Endocrinol Metab
  contributor:
    fullname: Febbraio
– volume: 8
  start-page: 144
  year: 2005
  end-page: 155
  ident: bb0140
  article-title: PAGE: parametric analysis of gene set enrichment
  publication-title: BMC Bioinformatics
  contributor:
    fullname: Volsky
– volume: 220
  start-page: 51
  year: 2004
  end-page: 58
  ident: bb0060
  article-title: Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha
  publication-title: Mol Cell Endocrinol
  contributor:
    fullname: Kim
– volume: 34
  start-page: S3
  year: 2000
  end-page: S8
  ident: bb0005
  article-title: Weight gain and hormone replacement therapy: are women's fears justified?
  publication-title: Maturitas
  contributor:
    fullname: van Seumeren
– volume: 8
  start-page: 538
  year: 2006
  end-page: 554
  ident: bb0030
  article-title: Meta-analysis: effect of hormone-replacement therapy on components of the metabolic syndrome in postmenopausal women
  publication-title: Diabetes Obes Metab
  contributor:
    fullname: Salpeter
– volume: 22
  start-page: 956
  year: 2006
  end-page: 964
  ident: bb0070
  article-title: Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets
  publication-title: Nutrition
  contributor:
    fullname: Song
– volume: 136
  start-page: 409
  year: 2006
  end-page: 414
  ident: bb0165
  article-title: Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice
  publication-title: J Nutr
  contributor:
    fullname: Duan
– volume: 209
  start-page: 613
  year: 1981
  end-page: 619
  ident: bb0130
  article-title: Purification and crystallization of rat liver fatty acid synthetase
  publication-title: Arch Biochem Biophys
  contributor:
    fullname: Linn
– volume: 54
  start-page: 1
  year: 2010
  end-page: 10
  ident: bb0100
  article-title: Consumption of barley
  publication-title: Mol Nutr Food Res
  contributor:
    fullname: Song
– volume: 11
  start-page: 477
  year: 2003
  end-page: 490
  ident: bb0020
  article-title: The estrogen antagonist EM-652 and dehydroepiandrosterone prevent diet- and ovariectomy-induced obesity
  publication-title: Obes Res
  contributor:
    fullname: Deshaies
– volume: 26
  start-page: 1103
  year: 2002
  end-page: 1109
  ident: bb0010
  article-title: Estrogen receptor beta is involved in the anorectic action of estrogen
  publication-title: Int J Obes Relat Metab Disord
  contributor:
    fullname: Ljima
– volume: 102
  start-page: 109
  year: 2000
  end-page: 126
  ident: bb0080
  article-title: Functional discovery via a compendium of expression profiles
  publication-title: Cell
  contributor:
    fullname: Armour
– volume: 23
  start-page: 429
  year: 2005
  end-page: 435
  ident: bb0085
  article-title: Pathways to the analysis of microarray data
  publication-title: Trends Biotechnol
  contributor:
    fullname: Vidal-Puig
– volume: 7
  start-page: 230
  year: 2000
  end-page: 235
  ident: bb0065
  article-title: Soy phytoestrogens improve radial arm maze performance in ovariectomized retired breeder rats and do not attenuate benefits of 17beta-estradiol treatment
  publication-title: Menopause
  contributor:
    fullname: Clarkson
– volume: 28
  start-page: 412
  year: 1985
  end-page: 429
  ident: bb0105
  article-title: Homeostasis model assessment: insulin resistance and
  publication-title: Diabetologia
  contributor:
    fullname: Rudenski
– volume: 138
  start-page: 1092
  year: 1997
  end-page: 1096
  ident: bb0155
  article-title: Influence of estrogenic status on the lipolytic activity of parametrial adipose tissue in vivo: an in situ microdialysis study
  publication-title: Endocrinol
  contributor:
    fullname: Negrel
– volume: 20
  start-page: 1464
  year: 2004
  end-page: 1465
  ident: bb0090
  article-title: GOstat: find statistically overrepresented gene ontologies within a group of genes
  publication-title: Bioinformatics
  contributor:
    fullname: Speed
– volume: Vol 10
  start-page: 245
  year: 1967
  end-page: 247
  ident: bb0115
  article-title: Cytochrome oxidase from beef heart mitochondria
  publication-title: Methods in enzymology
  contributor:
    fullname: Tzogaloff
– volume: 52
  start-page: 1085
  year: 2003
  end-page: 1091
  ident: bb0025
  article-title: Effects of tibolone and conjugated equine estrogens with or without medroxyprogesterone acetate on body composition and fasting carbohydrate measures in surgically postmenopausal monkeys
  publication-title: Metabolism
  contributor:
    fullname: Wagner
– volume: 58
  start-page: 38
  year: 2009
  end-page: 47
  ident: bb0015
  article-title: Modulation of insulin resistance in ovariectomized rats by endurance exercise training and estrogen replacement
  publication-title: Metabolism
  contributor:
    fullname: Toskulkao
– volume: 142
  start-page: 307
  year: 2000
  end-page: 314
  ident: bb0150
  article-title: Effect of long-term ovariectomy and estrogen replacement on the expression of estrogen rexeptor gene in female rats
  publication-title: Eur J Endocrinol
  contributor:
    fullname: Abdel-rahman
– volume: 262
  start-page: 5592
  year: 1987
  end-page: 5595
  ident: bb0045
  article-title: Genistein, a specific inhibitor of tyrosine-specific protein kinases
  publication-title: J Biol Chem
  contributor:
    fullname: Itoh
– volume: 31
  start-page: 19
  year: 2002
  end-page: 20
  ident: bb0135
  article-title: GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways
  publication-title: Nat Genet
  contributor:
    fullname: Conklin
– volume: 20
  start-page: 578
  year: 2004
  end-page: 580
  ident: bb0095
  article-title: FatiGO: a web tool for finding significant associations of gene ontology terms with groups of genes
  publication-title: Bioinformatics
  contributor:
    fullname: Dopazo
– volume: 120
  start-page: 237
  year: 1970
  end-page: 243
  ident: bb0110
  article-title: Factors influencing the activity of succinate dehydrogenase in membrane preparations from Micrococcus lysodeikticus
  publication-title: Biochem J
  contributor:
    fullname: Freer
– volume: 144
  start-page: 3315
  year: 2003
  end-page: 3320
  ident: bb0160
  article-title: The soy isoflavone genistein decreases adipose deposition in mice
  publication-title: Endocrinol
  contributor:
    fullname: Lubahn
– volume: 262
  start-page: 5592
  year: 1987
  ident: 10.1016/j.nutres.2012.10.002_bb0045
  article-title: Genistein, a specific inhibitor of tyrosine-specific protein kinases
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)45614-1
  contributor:
    fullname: Akiyama
– volume: 138
  start-page: 1092
  issue: 3
  year: 1997
  ident: 10.1016/j.nutres.2012.10.002_bb0155
  article-title: Influence of estrogenic status on the lipolytic activity of parametrial adipose tissue in vivo: an in situ microdialysis study
  publication-title: Endocrinol
  doi: 10.1210/endo.138.3.4984
  contributor:
    fullname: Darimont
– volume: 102
  start-page: 109
  year: 2000
  ident: 10.1016/j.nutres.2012.10.002_bb0080
  article-title: Functional discovery via a compendium of expression profiles
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)00015-5
  contributor:
    fullname: Hughes
– volume: 28
  start-page: 412
  year: 1985
  ident: 10.1016/j.nutres.2012.10.002_bb0105
  article-title: Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
  publication-title: Diabetologia
  doi: 10.1007/BF00280883
  contributor:
    fullname: Matthews
– volume: 8
  start-page: 538
  issue: 5
  year: 2006
  ident: 10.1016/j.nutres.2012.10.002_bb0030
  article-title: Meta-analysis: effect of hormone-replacement therapy on components of the metabolic syndrome in postmenopausal women
  publication-title: Diabetes Obes Metab
  doi: 10.1111/j.1463-1326.2005.00545.x
  contributor:
    fullname: Salpeter
– volume: 57
  start-page: 1176
  issue: 5
  year: 2008
  ident: 10.1016/j.nutres.2012.10.002_bb0055
  article-title: Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism
  publication-title: Diabetes
  doi: 10.2337/db07-0630
  contributor:
    fullname: Cederroth
– volume: 23
  start-page: 429
  year: 2005
  ident: 10.1016/j.nutres.2012.10.002_bb0085
  article-title: Pathways to the analysis of microarray data
  publication-title: Trends Biotechnol
  doi: 10.1016/j.tibtech.2005.05.011
  contributor:
    fullname: Curtis
– volume: 26
  start-page: 1103
  issue: 8
  year: 2002
  ident: 10.1016/j.nutres.2012.10.002_bb0010
  article-title: Estrogen receptor beta is involved in the anorectic action of estrogen
  publication-title: Int J Obes Relat Metab Disord
  doi: 10.1038/sj.ijo.0802054
  contributor:
    fullname: Liang
– volume: 281
  start-page: E803
  issue: 4
  year: 2001
  ident: 10.1016/j.nutres.2012.10.002_bb0035
  article-title: Effect of ovarian hormones on mitochondrial enzyme activity in the fat oxidation pathway of skeletal muscle
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.2001.281.4.E803
  contributor:
    fullname: Campbell
– volume: 20
  start-page: 578
  year: 2004
  ident: 10.1016/j.nutres.2012.10.002_bb0095
  article-title: FatiGO: a web tool for finding significant associations of gene ontology terms with groups of genes
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btg455
  contributor:
    fullname: Al-Shahrour
– volume: 278
  start-page: 680
  year: 1997
  ident: 10.1016/j.nutres.2012.10.002_bb0075
  article-title: Exploring the metabolic and genetic control of gene expression on a genomic scale
  publication-title: Science
  doi: 10.1126/science.278.5338.680
  contributor:
    fullname: DeRisi
– volume: Vol 10
  start-page: 245
  year: 1967
  ident: 10.1016/j.nutres.2012.10.002_bb0115
  article-title: Cytochrome oxidase from beef heart mitochondria
  contributor:
    fullname: Wharton
– volume: 22
  start-page: 956
  issue: 9
  year: 2006
  ident: 10.1016/j.nutres.2012.10.002_bb0070
  article-title: Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets
  publication-title: Nutrition
  doi: 10.1016/j.nut.2005.12.014
  contributor:
    fullname: Lee
– volume: 34
  start-page: S3
  year: 2000
  ident: 10.1016/j.nutres.2012.10.002_bb0005
  article-title: Weight gain and hormone replacement therapy: are women's fears justified?
  publication-title: Maturitas
  doi: 10.1016/S0378-5122(99)00073-0
  contributor:
    fullname: van Seumeren
– volume: 144
  start-page: 3315
  issue: 8
  year: 2003
  ident: 10.1016/j.nutres.2012.10.002_bb0160
  article-title: The soy isoflavone genistein decreases adipose deposition in mice
  publication-title: Endocrinol
  doi: 10.1210/en.2003-0076
  contributor:
    fullname: Naaz
– volume: 58
  start-page: 38
  issue: 1
  year: 2009
  ident: 10.1016/j.nutres.2012.10.002_bb0015
  article-title: Modulation of insulin resistance in ovariectomized rats by endurance exercise training and estrogen replacement
  publication-title: Metabolism
  doi: 10.1016/j.metabol.2008.08.004
  contributor:
    fullname: Saengsirisuwan
– volume: 50
  start-page: 509
  issue: 2
  year: 1972
  ident: 10.1016/j.nutres.2012.10.002_bb0125
  article-title: A rapid spectrophotometric assay for carnitine palmitoyltransferase
  publication-title: Anal Biochem
  doi: 10.1016/0003-2697(72)90061-9
  contributor:
    fullname: Bieber
– volume: 8
  start-page: 144
  issue: 6
  year: 2005
  ident: 10.1016/j.nutres.2012.10.002_bb0140
  article-title: PAGE: parametric analysis of gene set enrichment
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-6-144
  contributor:
    fullname: Kim
– volume: 120
  start-page: 237
  year: 1970
  ident: 10.1016/j.nutres.2012.10.002_bb0110
  article-title: Factors influencing the activity of succinate dehydrogenase in membrane preparations from Micrococcus lysodeikticus
  publication-title: Biochem J
  doi: 10.1042/bj1200237
  contributor:
    fullname: Owen
– volume: 132
  start-page: 3018
  issue: 10
  year: 2002
  ident: 10.1016/j.nutres.2012.10.002_bb0120
  article-title: Dietary alpha-linolenic acid–rich diacylglycerols reduce body weight gain accompanying the stimulation of intestinal beta-oxidation and related gene expressions in C57BL/KsJ-db/db mice
  publication-title: J Nutr
  doi: 10.1093/jn/131.10.3018
  contributor:
    fullname: Murase
– volume: 136
  start-page: 409
  issue: 2
  year: 2006
  ident: 10.1016/j.nutres.2012.10.002_bb0165
  article-title: Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice
  publication-title: J Nutr
  doi: 10.1093/jn/136.2.409
  contributor:
    fullname: Kim
– volume: 142
  start-page: 307
  year: 2000
  ident: 10.1016/j.nutres.2012.10.002_bb0150
  article-title: Effect of long-term ovariectomy and estrogen replacement on the expression of estrogen rexeptor gene in female rats
  publication-title: Eur J Endocrinol
  doi: 10.1530/eje.0.1420307
  contributor:
    fullname: Mohamed
– volume: 52
  start-page: 1085
  year: 2003
  ident: 10.1016/j.nutres.2012.10.002_bb0025
  article-title: Effects of tibolone and conjugated equine estrogens with or without medroxyprogesterone acetate on body composition and fasting carbohydrate measures in surgically postmenopausal monkeys
  publication-title: Metabolism
  doi: 10.1016/S0026-0495(03)00181-1
  contributor:
    fullname: Shadoan
– volume: 209
  start-page: 613
  issue: 2
  year: 1981
  ident: 10.1016/j.nutres.2012.10.002_bb0130
  article-title: Purification and crystallization of rat liver fatty acid synthetase
  publication-title: Arch Biochem Biophys
  doi: 10.1016/0003-9861(81)90320-9
  contributor:
    fullname: Linn
– volume: 220
  start-page: 51
  issue: 1–2
  year: 2004
  ident: 10.1016/j.nutres.2012.10.002_bb0060
  article-title: Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/j.mce.2004.03.011
  contributor:
    fullname: Kim
– volume: 20
  start-page: 1464
  year: 2004
  ident: 10.1016/j.nutres.2012.10.002_bb0090
  article-title: GOstat: find statistically overrepresented gene ontologies within a group of genes
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bth088
  contributor:
    fullname: Beissbarth
– volume: 3
  start-page: 6
  year: 2005
  ident: 10.1016/j.nutres.2012.10.002_bb0145
  article-title: Extragonadal aromatization increases with time after ovariectomy in rats
  publication-title: Reprod Biol Endocrinol
  doi: 10.1186/1477-7827-3-6
  contributor:
    fullname: Zhao
– volume: 11
  start-page: 477
  year: 2003
  ident: 10.1016/j.nutres.2012.10.002_bb0020
  article-title: The estrogen antagonist EM-652 and dehydroepiandrosterone prevent diet- and ovariectomy-induced obesity
  publication-title: Obes Res
  doi: 10.1038/oby.2003.65
  contributor:
    fullname: Lemieux
– volume: 31
  start-page: 19
  issue: 1
  year: 2002
  ident: 10.1016/j.nutres.2012.10.002_bb0135
  article-title: GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways
  publication-title: Nat Genet
  doi: 10.1038/ng0502-19
  contributor:
    fullname: Dahlquist
– volume: 54
  start-page: 1
  year: 2010
  ident: 10.1016/j.nutres.2012.10.002_bb0100
  article-title: Consumption of barley β-glucan ameliorates fatty liver and insulin resistance in mice fed a high-fat diet
  publication-title: Mol Nutr Food Res
  doi: 10.1002/mnfr.200900127
  contributor:
    fullname: Choi
– volume: 138
  start-page: 863
  issue: 3
  year: 1997
  ident: 10.1016/j.nutres.2012.10.002_bb0040
  article-title: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
  publication-title: Endocrinol
  doi: 10.1210/endo.138.3.4979
  contributor:
    fullname: Kuiper
– volume: 65
  start-page: 995
  year: 2004
  ident: 10.1016/j.nutres.2012.10.002_bb0050
  article-title: Dietary phytoestrogens and health
  publication-title: Phytochem
  doi: 10.1016/j.phytochem.2004.03.005
  contributor:
    fullname: Cornwell
– volume: 7
  start-page: 230
  issue: 4
  year: 2000
  ident: 10.1016/j.nutres.2012.10.002_bb0065
  article-title: Soy phytoestrogens improve radial arm maze performance in ovariectomized retired breeder rats and do not attenuate benefits of 17beta-estradiol treatment
  publication-title: Menopause
  doi: 10.1097/00042192-200007040-00004
  contributor:
    fullname: Pan
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Snippet Abstract Postmenopausal women are at higher risk for obesity and insulin resistance due to the decline of estrogen, but genistein, a phytoestrogen, may reduce...
Postmenopausal women are at higher risk for obesity and insulin resistance due to the decline of estrogen, but genistein, a phytoestrogen, may reduce the risks...
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SubjectTerms Adipose Tissue - cytology
Adipose Tissue - drug effects
Adipose Tissue - metabolism
Animals
Biological and medical sciences
Carnitine O-Palmitoyltransferase - metabolism
Diet, High-Fat - adverse effects
Dietary genistein
Dietary Supplements
Disease Models, Animal
Fatty Acid Synthases - metabolism
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
Gene Expression - drug effects
Genistein - pharmacology
Genistein - therapeutic use
Glycine max - chemistry
Insulin resistance
Insulin Resistance - genetics
Lipid Metabolism - drug effects
Lipid Metabolism - genetics
Liver - drug effects
Liver - enzymology
Microarray
Microarray Analysis
Mitochondrial function
Obesity - etiology
Obesity - genetics
Obesity - metabolism
Ovariectomy
Oxidation-Reduction
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - genetics
Phytoestrogens - pharmacology
Phytoestrogens - therapeutic use
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Postmenopause
Rat
Rats
Rats, Sprague-Dawley
Succinate Dehydrogenase - metabolism
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Weight Gain
β-Oxidation
Title Genistein reduced insulin resistance index through modulating lipid metabolism in ovariectomized rats
URI https://www.clinicalkey.es/playcontent/1-s2.0-S0271531712002114
https://dx.doi.org/10.1016/j.nutres.2012.10.002
https://www.ncbi.nlm.nih.gov/pubmed/23176795
Volume 32
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