Association between Endothelial Activation and Stress Index and mortality in diabetic nephropathy ICU patients: A retrospective cohort study

• Published in: PloS one Vol. 20; no. 8; p. e0329233
• Main Authors: Chen, Sheng, Guo, Lin, Ma, Xiaohan, Wang, Shuaikang, Wu, Junchao, Wu, Lingling, Zhang, Ting, Gao, Hongjun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.08.2025; Public Library of Science (PLoS)
• Subjects: Age; Aged; Biology and Life Sciences; Biomarkers; Blood platelets; Cardiac arrhythmia; Cardiovascular disease; Care and treatment; Comorbidity; Creatinine; Critical Illness - mortality; Dehydrogenases; Diabetes; Diabetes mellitus; Diabetic nephropathies; Diabetic Nephropathies - mortality; Diabetic Nephropathies - pathology; Diabetic Nephropathies - physiopathology; Diabetic nephropathy; Diagnosis; Endothelium; Endothelium, Vascular - physiopathology; Female; Health aspects; Heart failure; Hemoglobin; Hospital Mortality; Hospital patients; Hospitals; Human subjects; Humans; Inflammation; Intensive care; Intensive Care Units; Kaplan-Meier Estimate; Kinases; Male; Medical research; Medicine and Health Sciences; Medicine, Experimental; Middle Aged; Mortality; Nephropathy; Oxidative stress; Paralysis; Patient outcomes; Physiological aspects; Physiology; Prognosis; Proportional Hazards Models; Regression analysis; Respiratory failure; Retrospective Studies; Sepsis; Sodium; Statistical models; Subgroups; Survival; Therapeutic applications; Type 2 diabetes; Variables; China; United States > US; Massachusetts

Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, often leading to poor outcomes in critically ill patients. Endothelial Activation and Stress Index (EASIX), a marker of endothelial dysfunction and systemic stress, has been associated with adverse outcomes in various diseases...