Nutrient regulation of signaling and transcription

• Published in: The Journal of biological chemistry Vol. 294; no. 7; pp. 2211 - 2231
• Main Author: Hart, Gerald W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.02.2019; American Society for Biochemistry and Molecular Biology
• Subjects: Aging - metabolism; Aging - pathology; Alzheimer's disease; Animals; ASBMB Award; Caenorhabditis elegans - metabolism; Caenorhabditis elegans Proteins - metabolism; cancer; Chronic Disease; Cytoskeleton - metabolism; Cytoskeleton - pathology; diabetes; Diabetes Mellitus - metabolism; Diabetes Mellitus - pathology; Glycosylation; Humans; kinases; Mice; Mitochondria - metabolism; Mitochondria - pathology; N-Acetylglucosaminyltransferases - metabolism; Neoplasm Proteins - metabolism; Neoplasms - metabolism; Neoplasms - pathology; neurodegeneration; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Nutrients - metabolism; O-GlcNAcase; O-GlcNAcylation; O-linked N-acetylglucosamine (O-GlcNAc); O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT); Phosphorylation; Signal Transduction; Transcription, Genetic; O-linked N-acetylglucosamine (O-GlcNAc); kinases; O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT); neurodegeneration; O-GlcNAcase; O-GlcNAcylation; cancer; phosphorylation; diabetes; Alzheimer's disease

In the early 1980s, while using purified glycosyltransferases to probe glycan structures on surfaces of living cells in the murine immune system, we discovered a novel form of serine/threonine protein glycosylation (O-linked β-GlcNAc; O-GlcNAc) that occurs on thousands of proteins within the nucleus...