Effects of Combined Intrathecal Mesenchymal Stem Cells and Schwann Cells Transplantation on Neuropathic Pain in Complete Spinal Cord Injury: A Phase II Randomized Active-Controlled Trial

• Published in: Cell transplantation Vol. 34; p. 9636897241298128
• Main Authors: Akhlaghpasand, Mohammadhosein, Tavanaei, Roozbeh, Hosseinpoor, Maede, Heidari, Reza, Mohammadi, Ida, Chamanara, Mohsen, Hosseinpour, Melika, Zali, Alireza, Mosaed, Reza, Oraee-Yazdani, Saeed
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2025; Sage Publications Ltd; SAGE Publishing
• Subjects: Adult; Cell therapy; Clinical trials; Female; Humans; Injection; Injections, Spinal; Male; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Middle Aged; Multiple regression analysis; Neuralgia; Neuralgia - etiology; Neuralgia - therapy; Original; Pain; Patients; Quality of Life; Schwann cells; Schwann Cells - cytology; Schwann Cells - transplantation; Spinal cord injuries; Spinal Cord Injuries - complications; Spinal Cord Injuries - therapy; Stem cell transplantation; Stem cells; Treatment Outcome; Young Adult; spinal cord injury; mesenchymal stem cell; neuropathic pain; Schwann cell; stem cell therapy

Neuropathic pain is a debilitating complication following spinal cord injury (SCI). Currently, effective treatments for SCI-induced neuropathic pain are highly lacking. This clinical trial aimed to investigate the efficacy of combined intrathecal injection of Schwann cells (SCs) and bone marrow–deri...