Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives - Zou, Ling; Spanogiannopoulos, Peter; Pieper, Lindsey M.; Chien, Huan-Chieh; Cai, Wenlong; Khuri, Natalia; Pottel, Joshua; Vora, Bianca; Ni, Zhanglin; Tsakalozou, Eleftheria; Zhang, Wenjun; Shoichet, Brian K.; et al. (Proceedings of the National Academy of Sciences - PNAS, 2020)
Keywords: Absorption; Additives; Animals; Anti-Allergic Agents - metabolism; Anti-Allergic Agents - pharmacokinetics; ATP Binding Cassette Transporter, Subfamily B - genetics; ATP-Binding Cassette Sub-Family B Member 4; Azo Compounds; Azo dyes; Bacteria; Bacteria - isolation & purification; Bacteria - metabolism; Biological Sciences; Community structure; Digestive system; Drug additives; Dyes; Enzymatic activity; Excipients; Excipients - metabolism; Excipients - pharmacokinetics; Female; Fexofenadine; Food; Food additives; Food Additives - metabolism; Food Additives - pharmacokinetics; Food dyes; Gastrointestinal Microbiome - physiology; Gastrointestinal tract; Genetic diversity; Gnotobiotic; Histamine H1 Antagonists, Non-Sedating - metabolism; Histamine H1 Antagonists, Non-Sedating - pharmacokinetics; Humans; Hydrophobicity; Intestinal Absorption - drug effects; Intestinal Absorption - physiology; Intestinal microflora; Intestine; Male; Metabolites; Mice; Mice, Inbred BALB C; Mice, Knockout; Microbiomes; Microorganisms; Molecular weight; Organic Anion Transporters - metabolism; Pharmacokinetics; Pharmacovigilance; Substrates; Terfenadine - analogs & derivatives; azoreductases; food additives; drug absorption; excipients; human gut microbiome