Inhibition of Acute in vivo Human Immunodeficiency Virus Infection by Human Interleukin 10 Treatment of SCID Mice Implanted with Human Fetal Thymus and Liver

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 93; no. 7; pp. 3126 - 3131
• Main Authors: Kollmann, Tobias R., Pettoello-Mantovani, Massimo, Katopodis, Nikos F., Hachamovitch, Moshe, Rubinstein, Arye, Kim, Ana, Goldstein, Harris
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 02.04.1996; National Acad Sciences; National Academy of Sciences
• Subjects: AIDS/HIV; Animals; Antigens, CD - analysis; Blood; Blood plasma; Brain; Cytokines; Cytokines - biosynthesis; Dosage; Fetal Tissue Transplantation - immunology; Flow Cytometry; Gene Expression; HIV; HIV infections; HIV Infections - immunology; HIV Infections - prevention & control; HIV Infections - therapy; HIV-1 - physiology; Human immunodeficiency virus; Humans; Immunity (Disease); Infections; Interferon-gamma - biosynthesis; Interleukin-10 - therapeutic use; Liver; Liver Transplantation - immunology; Messenger RNA; Mice; Mice, SCID; Monocytes; Monocytes - immunology; Polymerase Chain Reaction; RNA, Viral - blood; Rodents; T lymphocytes; T-Lymphocytes - immunology; Thymus Gland - immunology; Thymus Gland - transplantation; Transplantation, Heterologous - immunology; Transplants & implants; Virus Replication

To improve the usefulness of in vivo models for the investigation of the pathophysiology of human immunodeficiency virus (HIV) infection, we modified the construction of SCID mice implanted with human fetal thymus and liver (thy/liv-SCID-hu mice) so that the peripheral blood of the mice contained si...