Levistilide A Exerts a Neuroprotective Effect by Suppressing Glucose Metabolism Reprogramming and Preventing Microglia Polarization Shift: Implications for Parkinson's Disease

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 4; p. 912
• Main Authors: Zhang, Mingjie, Duan, Congyan, Lin, Weifang, Wu, Honghua, Chen, Lu, Guo, Hong, Yu, Minyu, Liu, Qi, Nie, Yaling, Wang, Hong, Wang, Shaoxia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2024; MDPI
• Subjects: Acidification; AMP-Activated Protein Kinases - metabolism; Anti-Inflammatory Agents - therapeutic use; Brain; Cytokines; Development and progression; Dextrose; Disease; Flow cytometry; Glucose; Glucose - metabolism; Heterocyclic Compounds, Bridged-Ring; Humans; Inflammation; Levistilide A; Lipopolysaccharides - pharmacology; Medical research; Medicine, Experimental; Metabolic Reprogramming; Metabolism; Microglia; Microscopy; Nervous system; Neurons; Neuroprotective Agents - therapeutic use; NF-kappa B - metabolism; Parkinson Disease - drug therapy; Parkinson Disease - metabolism; Parkinson’s disease; Phosphorylation; Physiological aspects; Prevention; Prognosis; TOR Serine-Threonine Kinases - metabolism; Wang Hong; China; microglia; Parkinson’s disease; metabolic reprogramming; Levistilide A

The microglia, displaying diverse phenotypes, play a significant regulatory role in the development, progression, and prognosis of Parkinson's disease. Research has established that glycolytic reprogramming serves as a critical regulator of inflammation initiation in pro-inflammatory macrophage...