Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease - Vacher, Coralie; Garcia-Oroz, Lourdes; Rubinsztein, David C. (Human molecular genetics, 2005)
Keywords: Animals; Biological and medical sciences; Brain - metabolism; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Models, Animal; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Heat-Shock Proteins - genetics; Heat-Shock Proteins - physiology; Humans; Huntingtin Protein; Huntington Disease - genetics; Huntington Disease - metabolism; Huntington Disease - mortality; Medical sciences; Mice; Mice, Transgenic; Molecular and cellular biology; Motor Activity - genetics; Nerve Tissue Proteins - metabolism; Neurology; Nuclear Proteins - metabolism; Peptides - antagonists & inhibitors; Peptides - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - physiology; Weight Loss - genetics; Animal model; Nervous system diseases; Yeast; Rodentia; Huntington disease; Transgenic animal; Gene overexpression; Survival; Cerebral disorder; Genetic disease; Aggregation; Vertebrata; Mammalia; Mouse; Central nervous system disease; Genetics; Degenerative disease; Extrapyramidal syndrome