The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice

• Published in: The Journal of biological chemistry Vol. 293; no. 24; pp. 9188 - 9197
• Main Authors: Zuo, Xiaoli, Rong, Bowen, Li, Li, Lv, Ruitu, Lan, Fei, Tong, Ming-Han
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.06.2018; American Society for Biochemistry and Molecular Biology
• Subjects: Acrosome - metabolism; Acrosome - pathology; acrosome biogenesis; Animals; Carrier Proteins - genetics; Cells, Cultured; Developmental Biology; Gene Deletion; Gene Expression Regulation, Developmental; Histone Code; histone methylation; histone modification; Histone-Lysine N-Methyltransferase - genetics; histone-to-protamine transition; Infertility, Male - genetics; Infertility, Male - pathology; Male; Mice, Inbred C57BL; Mice, Knockout; Protamines - genetics; reproduction; Setd2; Spermatids - cytology; Spermatids - metabolism; Spermatids - pathology; Spermatogenesis; spermiogenesis; testis; histone methylation; Setd2; histone modification; acrosome biogenesis; spermatogenesis; histone-to-protamine transition; testis; spermiogenesis; reproduction

Spermatogenesis is precisely controlled by complex gene expression programs and involves epigenetic reprogramming, including histone modification and DNA methylation. SET domain–containing 2 (SETD2) is the predominant histone methyltransferase catalyzing the trimethylation of histone H3 lysine 36 (H...