Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 18; pp. 7373 - 7378
• Main Authors: Liu, Shixuan, Balasov, Maxim, Wang, Hongfei, Wu, Lijie, Chesnokov, Igor N, Liu, Yingfang
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 03.05.2011; National Acad Sciences
• Subjects: Amino Acid Sequence; Amino acids; Animalia; Animals; Binding sites; Biological Sciences; Bromodeoxyuridine; Cell culture; Chromatin; Chromatography, Gel; Chromosomes; Cloning, Molecular; Crystallization; Cultured cells; Cytokinesis; Data processing; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA replication; DNA Replication - genetics; Drosophila; Electrophoresis, Polyacrylamide Gel; Eukaryotes; eukaryotic cells; Green Fluorescent Proteins; Homology; Human subjects; Humans; in vitro culture; Lamins; Metazoa; Models, Molecular; Molecular Sequence Data; Origin recognition complex; Origin Recognition Complex - chemistry; Origin Recognition Complex - genetics; Promoters; Protein Binding; Protein Conformation; Proteins; Replication; Replication initiation; Replication origins; Sequence Alignment; Sequence Homology; Structural analysis; Transcription Factor TFIIB - genetics; Transcription factors; Transcription initiation factor TFIIB; Xenopus

The Origin Recognition Complex (ORC) is a six-subunit protein important for the initiation of DNA replication in eukaryotic cells. Orc6 is the smallest and the least conserved among ORC subunits. It is required for the DNA replication but also has a function in cytokinesis in metazoan species, howev...