The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism

• Published in: Progress in Lipid Research Vol. 41; no. 2; pp. 99 - 130
• Main Authors: Hunt, Mary C, Alexson, Stefan E.H
• Format: Book Review Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2002
• Subjects: acyl-CoA; acyl-CoA deacylase; acyl-CoA hydrolase; acyl-CoA thioester hydrolase; acyl-CoA thioesterase; Amino Acid Sequence; Animals; Brain - metabolism; Cloning, Molecular; Coenzyme A; Cytosol - enzymology; Humans; Lipid Metabolism; Liver - enzymology; Medicin och hälsovetenskap; Mitochondria - enzymology; Molecular Sequence Data; Peroxisome proliferator-activated receptor; Rats; Terminology as Topic; Thiolester Hydrolases - isolation & purification; Thiolester Hydrolases - physiology; β-oxidation; acyl-CoA; Peroxisome proliferator-activated receptor; acyl-CoA thioesterase; β-oxidation; Coenzyme A; acyl-CoA thioester hydrolase; acyl-CoA deacylase; Lipid metabolism; acyl-CoA hydrolase

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. These enzymes are localized in almost all cellular compartments su...