Investigation of discrepant mismatch repair immunohistochemistry and microsatellite instability polymerase chain reaction test results for gynecologic cancers using next-generation sequencing - Smithgall, Marie C.; Remotti, Helen; Hsiao, Susan J.; Mansukhani, Mahesh; Liu-Jarin, Xiaolin; Fernandes, Helen (Human pathology, 2022)
Keywords: Adult; Aged; Biomarkers; Biomarkers, Tumor - analysis; Biomarkers, Tumor - genetics; Biopsy; Colorectal cancer; Databases, Factual; DNA Mismatch Repair; DNA Mutational Analysis; DNA-Binding Proteins - antagonists & inhibitors; DNA-Binding Proteins - genetics; Endometrial cancer; FDA approval; Female; Genes; Genetic disorders; Genital Neoplasms, Female - diagnosis; Genital Neoplasms, Female - enzymology; Genital Neoplasms, Female - genetics; Genital Neoplasms, Female - pathology; Gynecologic cancer; Gynecology; High-Throughput Nucleotide Sequencing; Humans; Immunohistochemistry; Immunotherapy; Laboratories; Microsatellite Instability; Middle Aged; Mismatch Repair Endonuclease PMS2 - analysis; Mismatch Repair Endonuclease PMS2 - genetics; MMR; MSI; Mutation; MutL Protein Homolog 1 - analysis; MutL Protein Homolog 1 - genetics; NGS; Oncology; Ovarian cancer; Pathology; Polymerase Chain Reaction; Predictive Value of Tests; Reproducibility of Results; Retrospective Studies; Tumors; United States--US; Arizona; California; MSI; MMR; NGS; Gynecologic cancer