A Model for the Estimation of Hepatic Insulin Extraction After a Meal

• Published in: IEEE transactions on biomedical engineering Vol. 63; no. 9; pp. 1925 - 1932
• Main Authors: Piccinini, Francesca, Dalla Man, Chiara, Vella, Adrian, Cobelli, Claudio
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.09.2016; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Blood Glucose - metabolism; Carbohydrate Metabolism - physiology; Computer Simulation; Data models; Descriptions; Eating - physiology; Estimates; Extraction; Female; Glucose; Humans; Insulin; Insulin - blood; Insulin - metabolism; Insulin clearance; insulin kinetics; Insulin Secretion; Kinetic theory; Kinetics; Liver; Liver - metabolism; Male; Mathematical models; Meals; Metabolic Clearance Rate; Middle Aged; Models, Biological; Parameters; Plasmas; Postprandial Period - physiology; Solid modeling; Sugar

Goal: Quantitative assessment of hepatic insulin extraction (TIE) after an oral glucose challenge, e.g., a meal, is important to understand the regulation of carbohydrate metabolism. The aim of the current study is to develop a model of system for estimating TIE. Methods: Nine different models, of i...