Analysis of Early EEG Changes After Tocilizumab Treatment in New-Onset Refractory Status Epilepticus

• Published in: Brain sciences Vol. 15; no. 6; p. 638
• Main Authors: Shin, Yong-Won, Hong, Sang Bin, Lee, Sang Kun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.06.2025; MDPI
• Subjects: Analysis; Autoimmune diseases; Biomarkers; Case reports; Convulsions & seizures; Cytokines; Development and progression; EEG; Electroencephalography; Encephalitis; Entropy; Epilepsy; Etiology; Immunoglobulins; Immunotherapy; Interleukin 6; Interleukins; Monoclonal antibodies; Neural networks; Neurophysiology; new-onset refractory status epilepticus; Patients; quantitative EEG; Statistical analysis; Status epilepticus; tocilizumab; Trends; quantitative EEG; tocilizumab; new-onset refractory status epilepticus
• ISSN: 2076-3425; 2076-3425
• DOI: 10.3390/brainsci15060638

Background/Objectives: New-onset refractory status epilepticus (NORSE) is a rare neurologic emergency that often requires immunotherapy despite an unclear etiology and poor response to standard treatments. Tocilizumab, an anti-interleukin-6 monoclonal antibody, has shown promise in case reports; how...