Moderate Exercise Increases Expression for Sensory, Adrenergic, and Immune Genes in Chronic Fatigue Syndrome Patients But Not in Normal Subjects

• Published in: The journal of pain Vol. 10; no. 10; pp. 1099 - 1112
• Main Authors: Light, Alan R, White, Andrea T, Hughen, Ronald W, Light, Kathleen C
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2009
• Subjects: Acid Sensing Ion Channels; Adult; Anesthesia & Perioperative Care; ASIC; Catechol O-Methyltransferase - genetics; Catechol O-Methyltransferase - metabolism; Exercise Test; Exercise Tolerance - physiology; Fatigue; Fatigue Syndrome, Chronic - genetics; Fatigue Syndrome, Chronic - immunology; Fatigue Syndrome, Chronic - physiopathology; Female; Fibromyalgia - genetics; Fibromyalgia - immunology; Fibromyalgia - physiopathology; gene expression; Gene Expression Regulation - genetics; Gene Expression Regulation - immunology; Genetic Predisposition to Disease - genetics; Humans; Immune System - metabolism; Immune System - physiopathology; Interleukin-10 - genetics; Interleukin-10 - metabolism; leukocytes; Male; Middle Aged; muscle pain; Pain Medicine; Receptors, Adrenergic - genetics; Receptors, Adrenergic - metabolism; Receptors, Adrenergic, beta-2 - genetics; Receptors, Adrenergic, beta-2 - metabolism; Receptors, Cell Surface - genetics; Receptors, Cell Surface - metabolism; Receptors, Purinergic - genetics; Receptors, Purinergic - metabolism; RNA, Messenger - analysis; RNA, Messenger - metabolism; Sensory Receptor Cells - immunology; Sensory Receptor Cells - metabolism; Sodium Channels - genetics; Sodium Channels - metabolism; Sympathetic Nervous System - metabolism; Sympathetic Nervous System - physiopathology; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - metabolism; TRPV1; muscle pain; Fatigue; leukocytes; ASIC; TRPV1; gene expression

Abstract Chronic fatigue syndrome (CFS) is characterized by debilitating fatigue, often accompanied by widespread muscle pain that meets criteria for fibromyalgia syndrome (FMS). Symptoms become markedly worse after exercise. Previous studies implicated dysregulation of the sympathetic nervous syste...