Inhibition of miR-25 attenuates doxorubicin-induced apoptosis, reactive oxygen species production and DNA damage by targeting PTEN

• Published in: International journal of medical sciences Vol. 17; no. 10; pp. 1415 - 1427
• Main Authors: Li, Zhiqiang, Li, Hongqiang, Liu, Baoxin, Luo, Jiachen, Qin, Xiaoming, Gong, Mengmeng, Shi, Beibei, Wei, Yidong
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2020; Ivyspring International Publisher
• Subjects: Animals; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; Binding sites; Cell Line; Cell Survival - drug effects; Cell Survival - genetics; DNA damage; DNA Damage - drug effects; DNA Damage - genetics; Doxorubicin - pharmacology; Flow Cytometry; Gene expression; Heart failure; Laboratory animals; Manufacturers; Mice; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Rats; Reactive Oxygen Species - metabolism; Reagents; Research Paper; Beijing China; United States > US; China; Japan; PTEN; doxorubicin-induced cardiotoxicity; miR-25; H9c2 cells

: Doxorubicin (DOX) is one of the widely used anti-cancer drugs, whereas it can induce irreversible cardiac injury in a dose-dependent manner which limits its utility in clinic. Our study aimed to investigate the relationship between miR-25 and DOX-induced cardiac injury and its underlying mechanism...