Pharmacokinetics of thiamphenicol glycinate and its active metabolite by single and multiple intravenous infusions in healthy Chinese volunteers

• Published in: Xenobiotica Vol. 44; no. 9; pp. 819 - 826
• Main Authors: Yang, Bing, Li, Ning, Lu, Yang, Qiu, Zhixia, Zhao, Di, Song, Pengfei, Chen, Xijing
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.09.2014; Taylor & Francis; Informa UK Limited
• Subjects: Adult; Asian Continental Ancestry Group; Asian People; Body Mass Index; Body Weight; Clinical pharmacokinetics; Dose-Response Relationship, Drug; Double-Blind Method; Female; Healthy Volunteers; Humans; Infusions, Intravenous; Male; Thiamphenicol; Thiamphenicol - administration & dosage; Thiamphenicol - analogs & derivatives; Thiamphenicol - pharmacokinetics; Thiamphenicol - pharmacology; thiamphenicol glycinate; Young Adult; thiamphenicol; Clinical pharmacokinetics; thiamphenicol glycinate

Abstract 1. The aim of this study was to investigate the pharmacokinetics of thiamphenicol glycinate (TG) and thiamphenicol (TAP) after intravenous (i.v.) infusion of TG hydrochloride in healthy Chinese by evaluating the pharmacokinetic parameters, to provide clinical guidance in TG application. 2. ...