Ankylosing spondylitis: etiology, pathogenesis, and treatments

Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain; additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment h...

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Published inBone Research Vol. 7; no. 1; pp. 1 - 16
Main Authors Zhu, Wei, He, Xuxia, Cheng, Kaiyuan, Zhang, Linjie, Chen, Di, Wang, Xiao, Qiu, Guixing, Cao, Xu, Weng, Xisheng
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 05.08.2019
Springer Nature B.V
Subjects
692/420
692/699/317/821
Internal Medicine
Medicine
Medicine & Public Health
Orthopedics
Pathogenesis
Review
Review Article
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Abstract Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain; additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen (HLA)‑B27 and the interleukin‑23/17 axis. However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies.
AbstractList Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain; additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen (HLA)‑B27 and the interleukin‑23/17 axis. However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies.
Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain; additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen (HLA)‑B27 and the interleukin‑23/17 axis. However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies.Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain; additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen (HLA)‑B27 and the interleukin‑23/17 axis. However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies.
Author He, Xuxia
Weng, Xisheng
Zhu, Wei
Zhang, Linjie
Chen, Di
Qiu, Guixing
Cao, Xu
Wang, Xiao
Cheng, Kaiyuan
Author_xml – sequence: 1
  givenname: Wei
  surname: Zhu
  fullname: Zhu, Wei
  organization: Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
– sequence: 2
  givenname: Xuxia
  surname: He
  fullname: He, Xuxia
  organization: Department of Clinical Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College
– sequence: 3
  givenname: Kaiyuan
  surname: Cheng
  fullname: Cheng, Kaiyuan
  organization: Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
– sequence: 4
  givenname: Linjie
  surname: Zhang
  fullname: Zhang, Linjie
  organization: Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
– sequence: 5
  givenname: Di
  surname: Chen
  fullname: Chen, Di
  organization: Department of Orthopedic Surgery, Rush University Medical Center
– sequence: 6
  givenname: Xiao
  orcidid: 0000-0001-6395-706X
  surname: Wang
  fullname: Wang, Xiao
  organization: Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
– sequence: 7
  givenname: Guixing
  surname: Qiu
  fullname: Qiu, Guixing
  organization: Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
– sequence: 8
  givenname: Xu
  surname: Cao
  fullname: Cao, Xu
  email: xcao11@jhmi.edu
  organization: Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University
– sequence: 9
  givenname: Xisheng
  surname: Weng
  fullname: Weng, Xisheng
  email: xshweng@medmail.com.cn
  organization: Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
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Snippet Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing...
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Title Ankylosing spondylitis: etiology, pathogenesis, and treatments
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