Identification and transcriptome analysis of erythroblastic island macrophages

• Published in: Blood Vol. 134; no. 5; pp. 480 - 491
• Main Authors: Li, Wei, Wang, Yaomei, Zhao, Huizhi, Zhang, Huan, Xu, Yuanlin, Wang, Shihui, Guo, Xinhua, Huang, Yumin, Zhang, Shijie, Han, Yongshuai, Wu, Xianfang, Rice, Charles M., Huang, Gang, Gallagher, Patrick G., Mendelson, Avital, Yazdanbakhsh, Karina, Liu, Jing, Chen, Lixiang, An, Xiuli
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2019; American Society of Hematology
• Subjects: Animals; Biomarkers; Computational Biology - methods; Erythroblasts - metabolism; Erythropoiesis - genetics; Gene Expression; Gene Expression Profiling; Humans; Immunophenotyping; Macrophages - metabolism; Mice; Monocytes - metabolism; Receptors, Erythropoietin - genetics; Receptors, Erythropoietin - metabolism; Red Cells, Iron, and Erythropoiesis; Stem Cell Niche - genetics; Stress, Physiological; Transcriptome

The erythroblastic island (EBI), composed of a central macrophage and surrounding erythroid cells, was the first hematopoietic niche discovered. The identity of EBI macrophages has thus far remained elusive. Given that Epo is essential for erythropoiesis and that Epor is expressed in numerous nonery...