MicroRNA profiling of diagnostic needle aspirates from patients with pancreatic cancer

• Published in: British journal of cancer Vol. 107; no. 8; pp. 1354 - 1360
• Main Authors: Ali, S, Saleh, H, Sethi, S, Sarkar, F H, Philip, P A
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.10.2012; Nature Publishing Group
• Subjects: 631/208/191/2018; 631/337/384/331; 692/699/67/1504/1713; 692/700/139; Adenocarcinoma; Adenocarcinoma - genetics; Adenocarcinoma - pathology; Bioindicators; Biological and medical sciences; biomarkers; Biomedical and Life Sciences; Biomedicine; Biopsy, Needle; Cancer; Cancer Research; Clinical trials; Deregulation; Drug Resistance; Epidemiology; Feasibility Studies; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression Profiling; Histology; Humans; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; MicroRNAs; miRNA; Molecular Diagnostics; Molecular Medicine; Oligonucleotide Array Sequence Analysis; Oncology; Pancreatic cancer; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Polymerase chain reaction; RNA; Stratification; Tumors; fine-needle aspirates; pancreatic cancer; miRNAs; biomarker; qRT–PCR; Human; RNA interference; Micro RNA; Biological marker; Malignant tumor; Polymerase chain reaction; Gene silencing; Cancerology; Fine needle; Pancreas cancer; Digestive diseases; Diagnosis; Molecular biology; qRT―PCR; Cancer; Pancreatic disease

Background: A major challenge to the development of biomarkers for pancreatic cancer (PC) is the small amount of tissue obtained at the time of diagnosis. Single-gene analyses may not reliably predict biology of PC because of its complex molecular makeup. MicroRNA (miRNA) profiling may provide a mor...