The Role of Frontal Cortical and Medial-Temporal Lobe Brain Areas in Learning a Bayesian Prior Belief on Reversals

• Published in: The Journal of neuroscience Vol. 35; no. 33; pp. 11751 - 11760
• Main Authors: Jang, Anthony I., Costa, Vincent D., Rudebeck, Peter H., Chudasama, Yogita, Murray, Elisabeth A., Averbeck, Bruno B.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 19.08.2015
• Subjects: Animals; Bayes Theorem; Brain Mapping; Choice Behavior - physiology; Female; Frontal Lobe - physiology; Macaca; Macaca mulatta; Male; Memory - physiology; Nerve Net - physiology; Neuronal Plasticity - physiology; Reversal Learning - physiology; Reward; Temporal Lobe - physiology; reversal learning; learning set; orbitofrontal cortex; amygdala; medial prefrontal cortex; Bayesian prior

Reversal learning has been extensively studied across species as a task that indexes the ability to flexibly make and reverse deterministic stimulus-reward associations. Although various brain lesions have been found to affect performance on this task, the behavioral processes affected by these lesi...