Evolution of melanocortin receptors in cartilaginous fish: Melanocortin receptors and the stress axis in elasmobranches

Graphical abstract Highlights ► ACTH is a more potent ligand for activation of elephant shark MC3R than α-MSH. ► Dogfish MC3R, MC4R, MC5R can be activated by ACTH or the MSHs. ► It appears that the HPI axis in cartilaginous fishes can be activated by multiple ligands.

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Bibliographic Details
Published inGeneral and comparative endocrinology Vol. 181; pp. 4 - 9
Main Authors Liang, Liang, Reinick, Christina, Angleson, Joseph K, Dores, Robert M
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.01.2013
Subjects
Actinopterygii
Animals
Cartilaginous fish
Chondrichthyes
Elasmobranchii
Elasmobranchii - metabolism
Endocrinology & Metabolism
Evolution
Evolution, Molecular
Fishes - metabolism
Holocephali
Marine
MC3R
MC4R
MC5R
MCR
Models, Biological
Receptor, Melanocortin, Type 3 - metabolism
Receptor, Melanocortin, Type 4 - metabolism
Receptors, Melanocortin - metabolism
Sarcopterygii
MC4R
Cartilaginous fish
MC3R
Evolution
MCR
MC5R
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Summary:Graphical abstract Highlights ► ACTH is a more potent ligand for activation of elephant shark MC3R than α-MSH. ► Dogfish MC3R, MC4R, MC5R can be activated by ACTH or the MSHs. ► It appears that the HPI axis in cartilaginous fishes can be activated by multiple ligands.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
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ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2012.08.016