Social, communication, and cortical structural impairments in Epac2-deficient mice

• Published in: The Journal of neuroscience Vol. 32; no. 34; pp. 11864 - 11878
• Main Authors: Srivastava, Deepak P, Jones, Kelly A, Woolfrey, Kevin M, Burgdorf, Jeffrey, Russell, Theron A, Kalmbach, Abigail, Lee, Hyerin, Yang, Connie, Bradberry, Mazdak M, Wokosin, David, Moskal, Joseph R, Casanova, Manuel F, Waters, Jack, Penzes, Peter
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 22.08.2012
• Subjects: Animals; Dendritic Spines - genetics; Dendritic Spines - physiology; Exploratory Behavior - physiology; Female; Green Fluorescent Proteins - metabolism; Guanine Nucleotide Exchange Factors - deficiency; Guanine Nucleotide Exchange Factors - genetics; Locomotion - genetics; Male; Maze Learning - physiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons - cytology; Social Behavior; Somatosensory Cortex - cytology; Statistics, Nonparametric; Vocalization, Animal - physiology

Deficits in social and communication behaviors are common features of a number of neurodevelopmental disorders. However, the molecular and cellular substrates of these higher order brain functions are not well understood. Here we report that specific alterations in social and communication behaviors...